When Katy’s mother dies, she is left reeling. Carol wasn’t just Katy’s mom, but her best friend and first phone call. She had all the answers and now, when Katy needs her the most, she is gone. To make matters worse, their planned mother-daughter trip of a lifetime looms: to Positano, the magical town where Carol spent the summer right before she met Katy’s father. Katy has been waiting years for Carol to take her, and now she is faced with embarking on the adventure alone.

Daphne Bell believes the universe has a plan for her. Every time she meets a new man, she receives a slip of paper with his name and a number on it—the exact amount of time they will be together. The papers told her she’d spend three days with Martin in Paris; five weeks with Noah in San Francisco; and three months with Hugo, her ex-boyfriend turned best friend.

At the age of 29, Hannah Martin still has no idea what she wants to do with her life. She has lived in six different cities and held countless meaningless jobs since graduating college. On the heels of leaving yet another city, Hannah moves back to her hometown of Los Angeles and takes up residence in her best friend Gabby’s guestroom. Shortly after getting back to town, Hannah goes out to a bar one night with Gabby and meets up with her high school boyfriend, Ethan. Just after midnight, Gabby asks Hannah if she’s ready to go. A moment later, Ethan offers to give her a ride.

Nisha Cantor lives the globetrotting life of the seriously wealthy, until her husband announces a divorce and cuts her off. Nisha is determined to hang onto her glamorous life. But in the meantime, she must scramble to cope--she doesn’t even have the shoes she was, until a moment ago, standing in. That’s because Sam Kemp—in the bleakest point of her life—has accidentally taken Nisha’s gym bag. But Sam hardly has time to worry about a lost gym bag—she’s struggling to keep herself and her family afloat.

In a sleepy seaside town in Maine, recently widowed Eveleth "Evvie" Drake rarely leaves her large, painfully empty house nearly a year after her husband’s death in a car crash. Everyone in town, even her best friend, Andy, thinks grief keeps her locked inside, and Evvie doesn’t correct them. Meanwhile, in New York City, Dean Tenney, former Major League pitcher and Andy’s childhood best friend, is wrestling with what miserable athletes living out their worst nightmares call the "yips": he can’t throw straight anymore, and, even worse, he can’t figure out why.