Days after being dumped by her boyfriend Marc in Paris - "he was heading off to an ashram and said we could communicate telepathically" - Hattie hears her sister Min has been checked into a psychiatric hospital, and finds herself flying back to Winnipeg to take care of Thebes and Logan, her niece and nephew. Not knowing what else to do, they set out on a road trip in search of the children's long-lost father, Cherkis. On their wayward journey, the Troutmans stay at scary motels, meet helpful hippies, and try to ignore the threatening noises coming from under the hood of their van.

Sixteen-year-old Nomi Nickel longs to hang out with Lou Reed and Marianne Faithfull in New York City's East Village. Instead she's trapped in East Village, Manitoba, a small town whose population is Mennonite: "the most embarrassing sub-sect of people to belong to if you're a teenager." East Village is a town with no train and no bar whose job prospects consist of slaughtering chickens at the Happy Family Farms abattoir or churning butter for tourists at the pioneer village.

Elf and Yoli are sisters. While on the surface Elfrieda's life is enviable (she's a world-renowned pianist, glamorous, wealthy, and happily married,) and Yolandi's a mess (she's divorced and broke, with two teenagers growing up too quickly), they are fiercely close - raised in a Mennonite household and sharing the hardship of Elf's desire to end her life.

For Susan Green, messy emotions don’t fit into the equation of her perfectly ordered life. She has a flat that is ideal for one, a job that suits her passion for logic, and an “interpersonal arrangement” that provides cultural and other more intimate benefits. But suddenly confronted with the loss of her mother and the news that she is about to become a mother herself, Susan’s greatest fear is realized. She is losing control.

Shuggie’s mother Agnes walks a wayward path: She is Shuggie’s guiding light but a burden for him and his siblings. She dreams of a house with its own front door while she flicks through the pages of the Freemans catalogue, ordering a little happiness on credit, anything to brighten up her grey life. Married to a philandering taxi-driver husband, Agnes keeps her pride by looking good - her beehive, make-up, and pearly-white false teeth offer a glamourous image of a Glaswegian Elizabeth Taylor.