Joan has spent a lifetime enduring the cruelties of men. But when one of them commits a shocking act of violence in front of her, she flees New York City in search of Alice, the only person alive who can help her make sense of her past. In the sweltering hills above Los Angeles, Joan unravels the horrific event she witnessed as a child - that has haunted her every waking moment - while forging the power to finally strike back.

Irina obsessively takes explicit photographs of the average-looking men she persuades to model for her, scouted from the streets of Newcastle. Placed on sabbatical from her dead-end bar job, she is offered an exhibition at a fashionable London gallery, promising to revive her career in the art world and offering an escape from her rut of drugs, alcohol and extreme cinema. The news triggers a self-destructive tailspin, centred around Irina's relationship with her obsessive best friend and a shy young man from her local supermarket who has attracted her attention....

Our narrator should be happy, shouldn't she? She's young, thin, pretty, a recent Columbia graduate; she works an easy job at a hip art gallery and lives in an apartment on the Upper East Side of Manhattan paid for, like the rest of her needs, by her inheritance. But there is a dark and vacuous hole in her heart, and it isn't just the loss of her parents, or the way her Wall Street boyfriend treats her, or her sadomasochistic relationship with her best friend, Reva. It's the year 2000 in a city aglitter with wealth and possibility; what could be so terribly wrong?

An ambitious mother puts her art career on hold to stay at home with her newborn son, but the experience does not match her imagination. Two years later, she steps into the bathroom for a break from her toddler's demands, only to discover a dense patch of hair on the back of her neck. In the mirror, her canines suddenly look sharper than she remembers. Her husband, who travels for work five days a week, casually dismisses her fears from faraway hotel rooms.

2000. Bright, ambitious, and yearning for adulthood, 15-year-old Vanessa Wye becomes entangled in an affair with Jacob Strane, her magnetic and guileful 42-year-old English teacher. 2017. Amid the rising wave of allegations against powerful men, a reckoning is coming due. Strane has been accused of sexual abuse by a former student, who reaches out to Vanessa, and now Vanessa suddenly finds herself facing an impossible choice: Remain silent, firm in the belief that her teenage self willingly engaged in this relationship, or redefine herself and the events of her past.