When Lilith lyapo wakes from a centuries-long sleep, she finds herself aboard the vast spaceship of the Oankali. She discovers that the Oankali—a seemingly benevolent alien race—intervened in the fate of the humanity hundreds of years ago, saving everyone who survived a nuclear war from a dying, ruined Earth and then putting them into a deep sleep. After learning all they could about Earth and its beings, the Oankali healed the planet, cured cancer, increased human strength, and they now want Lilith to lead her people back to Earth—but salvation comes at a price.

For a thousand years, Doro has cultivated a small African village, carefully breeding its people in search of seemingly unattainable perfection. He survives through the centuries by stealing the bodies of others, a technique he has so thoroughly mastered that nothing on Earth can kill him. But when a gang of New World slavers destroys his village, ruining his grand experiment, Doro is forced to go west and begin anew. He meets Anyanwu, a centuries-old woman whose means of immortality are as kind as his are cruel. Now they begin a struggle that will last centuries.

Mary is a treacherous experiment. Her creator, an immortal named Doro, has molded the human race for generations, seeking out those with unusual talents like telepathy and breeding them into a new subrace of humans who obey his every command. The result is Mary: a young black woman living on the rough outskirts of Los Angeles in the 1970s, who has no idea how much power she will soon wield.

Having just celebrated her 26th birthday in 1976 California, Dana, an African-American woman, is suddenly and inexplicably wrenched through time into antebellum Maryland. After saving a drowning White boy there, she finds herself staring into the barrel of a shotgun and is transported back to the present just in time to save her life. During numerous such time-defying episodes with the same young man, she realizes she's been given a challenge.

God is change. That is the central truth of the Earthseed movement, whose unlikely prophet is 18-year-old Lauren Olamina. The young woman's diary entries tell the story of her life amid a violent 21st-century hell of walled neighborhoods and drug-crazed pyromaniacs - and reveal her evolving Earthseed philosophy. Against a backdrop of horror emerges a message of hope: if we are willing to embrace divine change, we will survive to fulfill our destiny among the stars.