Nasal Spray Blunts Traumatic Brain Injury
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Nasal Spray Blunts Traumatic Brain Injury
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So say neurologists at Harvard’s Brigham and Women’s Hospital. In a mouse model, they show that a nasal spray containing an anti-CD3 monoclonal antibody significantly reduces brain inflammation and speeds recovery after a traumatic brain injury (TBI).
This antibody, sprayed into the nasal cavities, activates regulatory T cells, Tregs, that then travel to the brain and release IL-10 that in turn reduces microglial-medial inflammation there.
This anti-CD3 nasal spray must still prove its effectiveness in humans. If so, it will become a treatment for the TBI that follows concussions, motor vehicle accidents, and other sports-related head trauma.
https://www.nature.com/articles/s41593-025-01877-7
#traumaticbraininjury #tbi #sports #cd3 #treg #il10 #mva #nasalspray