Jewel is Hollywood royalty; as the teenage star of the TV show Daddy's Girl, her face is instantly recognizable all across America. Now, though, she wants two things: to get a serious education and to leave her controlling stage-mother behind. Regina is the definitive upper-middle-class African-American girl. Her picture-perfect parents are what she calls "black Ward and June Cleavers", and their goals for her are like a stranglehold. No one can see, though, how far Regina's rebellious side will take her, or how treacherous it will become. Carmen is just trying to get by. A child of the projects whose father is dead and whose mother has vanished, Carmen has been raised by her abusive brother. Columbia is the way for her to get a better life, if she can hold down two jobs and keep her grade point average up.

When the three of them meet, their lives are at a crossroad. And as the years progress, from the 1980s to the present day, they are challenged by drug addiction, fame, secrets from the past, sickness, betrayal, and the darkest things women can face. One of them won't survive. But what will be the lasting legacy of their friendship? Better Than I Know Myself is a novel of heartache, triumph, tears, and the unshakeable bonds among women.