Kelly’s new life in Philadelphia has turned into a nightmare: She’s friendless and jobless, and the lockdown has her trapped in a tiny apartment with the man she gave up everything for, who’s just called off their wedding. The only bright spot is her newly rekindled friendship with her childhood friend Sabrina—now a glamorous bestselling author with a handsome, high-powered husband. When Sabrina and Nathan offer Kelly an escape hatch, volunteering the spare room of their remote Virginia mansion, she jumps at the chance to run away from her old life.

After a tragic chain of events led to the deaths of their spouses two years ago, D.C. philanthropist Sloane Chase and Senator Whit Montgomery are finally starting to move on. The horrifying ordeal drew them together, and now they're ready to settle down again—with each other. As Sloane returns to the world of White House dinners and political small talk, this time with her new husband, she's also preparing for an upcoming hip replacement—the latest reminder of the lupus diagnosis she's managed since her twenties.

Annabel, Esther, Tanya, and Chloe are best friends—or were, as children. Despite drifting apart in adulthood, shared secrets have kept them bonded for better or worse, even as their childhood dreams haven’t quite turned out as they’d hoped. Then one day they receive a wholly unexpected—but not entirely unwelcome—invitation from another old friend. Poppy Greer has invited them all to her extravagant bachelorette party: a first-class plane ticket to three days of white sand, cocktails, and relaxation on a luxe private island in the Bahamas.

Grace Evans, an overworked New Yorker looking for a total escape from her busy life, books an Airbnb on a ranch in the middle of Wyoming. When she arrives at the idyllic getaway, she’s pleased to find that the owner is a handsome man by the name of Calvin Wells—and he’s eager to introduce her to his easygoing way of life. But there are things Grace discovers that she’s not too pleased about: A lack of cell phone service. A missing woman. And a feeling that something isn’t right with the ranch.

Mia, the irreverent, hyperanalytical twenty-year-old daughter, has an explanation for everything—which is why she isn’t initially concerned when her father and younger brother Eugene don’t return from a walk in a nearby park. They must have lost their phone. Or stopped for an errand somewhere. But by the time Mia’s brother runs through the front door bloody and alone, it becomes clear that the father in this tight-knit family is missing and the only witness is Eugene, who has the rare genetic condition Angelman syndrome and cannot speak.