In downtown Chicago, a young woman named Esther Vaughan disappears from her apartment without a trace. A haunting letter addressed to "My Dearest" is found among her possessions, leaving her friend and roommate, Quinn Collins, to wonder where Esther is and whether or not she's the person Quinn thought she knew....

Sadie and Will Foust have only just moved their family from bustling Chicago to small-town Maine when their neighbor Morgan Baines is found dead in her home. The murder rocks their tiny coastal island, but no one is more shaken than Sadie. But it’s not just Morgan’s death that has Sadie on edge. And as the eyes of suspicion turn toward the new family in town, Sadie is drawn deeper into the mystery of what really happened that dark and deadly night.

Jake Hayes is missing. This much is certain. At first, his wife, Nina, thinks he is blowing off steam at a friend’s house after their heated fight the night before. But then a day goes by. Two days. Five. And Jake is still nowhere to be found. Lily Scott, Nina’s friend and coworker, thinks she may have been the last to see Jake before he went missing. After Lily confesses everything to her husband, Christian, the two decide that nobody can find out what happened leading up to Jake’s disappearance, especially not Nina.

Jessie Sloane is on the path to rebuilding her life after years of caring for her ailing mother. She rents a new apartment and applies for college. But when the college informs her that her social security number has raised a red flag, Jessie discovers a shocking detail that causes her to doubt everything she’s ever known. Meanwhile, 20 years earlier and 250 miles away, another woman’s split-second decision may hold the key to Jessie’s secret past. Has Jessie’s whole life been a lie, or have her delusions gotten the best of her?

Shelby Tebow is the first to go missing. Not long after, Meredith Dickey and her six-year-old daughter, Delilah, vanish just blocks away from where Shelby was last seen, striking fear into their once-peaceful community. Are these incidents connected? After an elusive search that yields more questions than answers, the case eventually goes cold. Now, 11 years later, Delilah shockingly returns. Everyone wants to know what happened to her, but no one is prepared for what they'll find....

Christopher and Hannah are a happily married surgeon and nurse with picture-perfect lives. All that’s missing is a child. When Janie, an abandoned six-year-old, turns up at their hospital, Christopher forms an instant connection with her, and he convinces Hannah they should take her home as their own.

Newly minted doctor Jane McGill is in hell. Not literally, of course. But between her drug addict patients, sleepless nights on call, and battling wits with the sadistic yet charming Sexy Surgeon, Jane can’t imagine an afterlife much worse than her first month of medical internship at County Hospital. And then there’s the devil herself: Jane’s senior resident Dr. Alyssa Morgan. When Alyssa becomes absolutely hell-bent on making her new interns pay tenfold for the deadly sin of incompetence, Jane starts to worry that she may not make it through the year with her soul or her sanity still intact.

Jackson is aggressive, confrontational and often volatile. His mother, Kayla, is crippled with grief after tragically losing her husband and eldest son. Struggling to cope, she puts Jackson into foster care. Cathy, his carer, encourages Jackson to talk about what has happened to his family, but he just won’t engage. His actions continue to test and worry everyone. Then, in a dramatic turn of events, the true reason for Jackson’s behaviour comes to light....

Emma can’t sleep. It’s been like this since her big 4-0 started getting closer. Her mother stopped sleeping just before her own fortieth birthday. She went mad and did the unthinkable because of it. Is that what’s happening to Emma?

Frankie Elkin is an average middle-aged woman, a recovering alcoholic with more regrets than belongings. But she spends her life doing what no one else will - searching for missing people the world has stopped looking for. When the police have given up, when the public no longer remembers, when the media has never paid attention, Frankie starts looking. A new case brings her to Mattapan, a Boston neighborhood with a rough reputation. She is searching for Angelique Badeau, a Haitian teenager who vanished from her high school months earlier.