In 1870, Mariah Stover is left for dead and with no memory when the Deadeye Gang robs the stagecoach she's on, killing her father and brother. As she takes over her father's blacksmith business and attempts to move forward, the old-fashioned townspeople meet her new occupation with disdain.

Haunted by the horrors of war, ex-cavalry officer Matthew Hanger leads a band of mercenaries known as Hanger's Horsemen who have become legends in 1890s Texas. They defend the innocent and obtain justice for the oppressed. But when a rustler's bullet leaves one of them at death's door, they're the ones in need of saving. Dr. Josephine Burkett is used to men taking one look at her skirts and discounting her medical skills. What she's not used to is having a man change his mind in a heartbeat and offer to assist her in surgery.

Katherine Schneider’s life as a dentist in 1913 New York is upended when a patient reveals details of a deadly plot while under the influence of laughing gas. As she is plunged into danger, she seeks help from the dashing Lieutenant Jonathan Birch, a police officer she has long admired from afar.

Greta Nilsson's trip west to save her ailing little sister, Astrid, could not have gone more wrong. First, bandits hold up her stagecoach, stealing all her money. Then, upon arriving in Fairplay, Colorado, she learns the man she was betrothed to as a mail-order bride has died. Homeless, penniless, and jobless, Greta and her sister are worse off than when they started.

Upon uncovering her tyrannical father’s malevolent plot to commit her to an asylum, Beth Rutledge fabricates a plan of her own. She will rescue her mother, who had already been sent to the asylum, and escape together on a wagon train heading west. Posing as sisters, Beth and her mother travel with the pioneers in hopes of making it to Idaho before the others start asking too many questions.