In the heart of the South Pacific lies Point Nemo, the most desolate and remote place on Earth. At its core is a dead zone, devoid of life, where government agencies crash their obsolete satellites and space stations, confident they won't harm a soul. When the International Space Station suffers a catastrophic failure and plummets through the atmosphere, it's here that Mission Specialist Julie Rohr, an astrobiologist studying living space dust called xylem, finds herself marooned. Julie's only hope for rescue lies in the hands of her estranged father, Dr. Finn Maddern, a renowned mycologist.

The Galahad, a faster-than-light spacecraft, carries 50 scientists and engineers on a mission to prepare Kepler 452b, Earth's nearest habitable neighbor at 1400 light years away. With Earth no longer habitable and the Mars colony slowly failing, they are humanity's best hope. After 10 years in a failed cryogenic bed - body asleep, mind awake - William Chanokh's torture comes to an end as the fog clears, the hatch opens, and his friend and fellow hacker, Tom, greets him...by stabbing a screwdriver into his heart. This is the first time William dies.

In the middle of the night, an explosion rocks Cambridge, Massachusetts and wakes Saul Signalman from bed. Blue, ethereal light pulses into the sky. A FaceTime call pulls him away from the view. It’s his wife, consumed in light, bidding him farewell. And then - the call ends. The explosion of light intensifies. The power goes out. Electronic devices stop working. In the dead of night, he races to his wife’s lab at the explosion’s core, but the building is missing. His wife is gone.

A chain of subglacial volcanoes erupt in Iceland. The melting ice floods the countryside. Poisonous gas descends on Scotland. A tsunami devastates the Norwegian coastline. An ash cloud rises into the atmosphere, blotting out the sun across Europe, ushering in a new Ice Age. Dozens of nuclear power plants, flooded by ocean water, experience meltdowns. Millions perish. Many more are displaced. All on the first day.

Stranded in the Amazon rainforest, a lost man fights for survival and discovers that the root of evil doesn’t just reside in the world’s darkest corners, but inside the hearts of all mankind. Dr. Gregory Zekser is on a mission to visit the furthest reaches of the Amazon, providing medical aid to recently contacted tribes. As a general practitioner and food pantry director, his life in Massachusetts can be chaotic, but serving people is what he does best, and he doesn’t mind sacrificing his personal life to help others, at home or halfway around the world.