Newly minted San Francisco police detective Manhattan Sloane lets no one get close. Especially lovers. Sloane has her reasons for keeping the world at arm's length. But then her first childhood crush, DEA Agent Finn Harper, reappears and changes everything. Harper has arrived in San Francisco to investigate a new street drug weaving its way into the city - a drug that has personal ties for Sloane. The two find themselves thrown together as they team up to take down a ruthless cartel lord. Soon, sparks fly as old feelings surface.

Ellie Fisher loves most things about being a nurse in the emergency department . . . just not working with Regina Novak, an icy attending physician who acts as if she's God's gift to medicine. The dislike is completely mutual. Regina thinks Ellie is a starry-eyed romantic with a sentimental attitude that has no place at work. When Regina gets talked into volunteering at a singles auction, Ellie accidentally bids on her—and ends up winning. Oops! Since the money raised is for a good cause, they reluctantly decide to go through with the dates.

When professional soccer player Alex Grey goes on a vacation to the local South Carolina islands, she isn't anticipating any life-changing events. Just a relaxing weekend to prepare for the upcoming season. But that quickly changes when she finds herself the lone witness to a sailing accident and makes the decision to risk her own life to save a drowning woman—unwittingly coming to the rescue of a US senator's wife, Catharine Cleveland.

Tired of disappointing dates with men, Dakota is convinced true love has passed her by. But when her lesbian friends convince her to include women in her dating app options, she instantly hits it off with NYPD detective Jack.

Unemployed academic Caitlyn Taylor comes home to family drama. Her carefree twin Chloe plans to ditch her job to visit a guy she met online. Caitlyn steps in to impersonate Chloe so she won't get fired for skipping town. Unfortunately, this means answering phones for an icy, dismissive boss. Busy college president Ruth Holloway never paid much attention to her mediocre assistant. Suddenly, "Chloe" demonstrates insight into faculty politics and a baffling talent for analytics. And since when has she been so attractive?