Twenty-eight-year-old Sean McGillin is the picture of health, until he fractures his leg while in-line skating in New York City's Central Park. Within 24 hours of his surgery, he dies.

Twenty-three-year-old Michael “Mitt” Fuller starts his surgical residency with great anticipation at the nearly three-hundred-year-old, iconic Bellevue Hospital, following in the footsteps of four previous, celebrated Fuller generations. The pressure is on for this newly minted doctor, and to his advantage he’s always had a secret sixth sense, a sensitivity to the nonphysical. But quickly one patient after another assigned to his care begin to die from mysterious causes.

Newly minted chief resident at Boston Memorial Hospital Noah Rothauser is swamped in his new position, from managing the surgical schedules to dealing with the fallouts from patient deaths. Known for its medical advances, the famed teaching hospital has fitted several ORs as "hybrid operating rooms of the future" - an improvement that seems positive until an anesthesia error during a routine procedure results in the death of an otherwise healthy man.

They called it "minor surgery", but Nancy Greenly, Sean Berman, and a dozen others - all admitted to Boston Memorial Hospital for routine procedures - were victims of the same inexplicable, hideous tragedy on the operating table. They never woke up...

Trying to find some normalcy during the COVID-19 pandemic, Brian Murphy and his family are on a summer excursion in Cape Cod when his wife, Emma, comes down with concerning flu-like symptoms. But their leisurely return home to New York City quickly becomes a race to the local hospital as she suddenly begins seizing in the car. At the ICU, she is diagnosed with eastern equine encephalitis, a rare and highly lethal mosquito-borne viral disease seemingly caught during one of their evening cookouts.