Thelonious "Monk" Ellison's writing career has bottomed out: his latest manuscript has been rejected by seventeen publishers, which stings all the more because his previous novels have been "critically acclaimed." He seethes on the sidelines of the literary establishment as he watches the meteoric success of We's Lives in Da Ghetto, a first novel by a woman who once visited "some relatives in Harlem for a couple of days."

When the enslaved Jim overhears that he is about to be sold to a man in New Orleans, separated from his wife and daughter forever, he decides to hide on nearby Jackson Island until he can formulate a plan. Meanwhile, Huck Finn has faked his own death to escape his violent father, recently returned to town. As all listeners of American literature know, thus begins the dangerous and transcendent journey by raft down the Mississippi River toward the elusive and too-often-unreliable promise of the Free States and beyond.

The Barnes family is in trouble. Dickie’s once-lucrative car business is going under—but Dickie is spending his days in the woods, building an apocalypse-proof bunker with a renegade handyman. His wife, Imelda, is selling off her jewelry on eBay and half-heartedly dodging the attention of fast-talking cattle farmer Big Mike, while their teenage daughter, Cass, formerly top of her class, seems determined to binge drink her way through her final exams. As for twelve-year-old PJ, he’s on the brink of running away.

At the moment when Voyager 1 is launched into space carrying its famous golden record, a baby of unusual perception is born to a single mother in Philadelphia. Adina Giorno is tiny and jaundiced, but reaches for warmth and light. As a child, she recognizes that she's different: she possesses knowledge of a faraway planet. The arrival of a fax machine enables her to contact her extraterrestrial relatives, beings who have sent her to report on the oddities of earthlings.

Star, a young survivor of the Sand Creek Massacre, is brought to the Fort Marion prison castle, where he is forced to learn English and practice Christianity by Richard Henry Pratt, an evangelical prison guard who will go on to found the Carlisle Indian Industrial School, an institution dedicated to the eradication of Native history, culture, and identity. A generation later, Star’s son, Charles, is sent to the school, where he is brutalized by the man who was once his father’s jailer. Under Pratt’s harsh treatment, Charles clings to moments he shares with a young fellow student, Opal Viola.