Bartholomew Lampion is born on a day of tragedy and terror that will mark his family forever. All agree that his unusual eyes are the most beautiful they have ever seen. On this same day, a thousand miles away, a ruthless man learns that he has a mortal enemy named Bartholomew. He embarks on a relentless search to find this enemy, a search that will consume his life. And a girl is born from a brutal rape, her destiny mysteriously linked to Barty and the man who stalks him.

A writer in California. A doctor in Boston. A motel owner and his employee in Nevada. A priest in Chicago. A robber in New York. A little girl in Las Vegas. They’re a handful of people from across the country, living through eerie variations of the same nightmare.

Jimmy Tock comes into the world on the very night his grandfather leaves it. As a violent storm rages outside the hospital, Rudy Tock spends long hours walking the corridors between the expectant fathers' waiting room and his dying father's bedside. It's a strange vigil made all the stranger when, at the very height of the storm's fury, Josef Tock suddenly sits up in bed and speaks coherently for the frist and last time since his stroke. What he says before he dies is that there will be five dark days in the life of his grandson.

Michael Mace, head of security at a top-secret research facility, opens his eyes in a makeshift morgue twenty-four hours following an event in which everyone perished—including him and his best friend, Shelby Shrewsberry. Having awakened with an extraordinary ability unlike anything he—or anyone else—has ever imagined, Michael is capable of being as elusive as a ghost. He sets out to honor his late friend by helping Nina Dozier and her son, John, whom Shelby greatly admired.

On his thirty-sixth birthday, Travis Cornell hikes into the foothills of the Santa Ana Mountains. But his path is soon blocked by a bedraggled Golden Retriever who will let him go no further into the dark woods. That morning, Travis had been desperate to find some happiness in his lonely, seemingly cursed life. What he finds is a dog of alarming intelligence that soon leads him into a relentless storm of mankind’s darkest creation....