Single mom Robyn Caldwell needs a new plan for her future. She has always put her family first. Now, with her kids grown, she yearns for a change. But what can she do when her daughter has become the most demanding bride ever, her son won’t even consider college, her best friend is on the brink of marital disaster and her ex is making a monumentally bad decision that could ruin everything?

Wanted: Midwife/nurse practitioner in Virgin River, population 600. Make a difference against a backdrop of towering California redwoods and crystal clear rivers. Rent-free cabin included. When the recently widowed Melinda Monroe sees this ad, she quickly decides that the remote mountain town of Virgin River might be the perfect place to escape her heartache and to reenergize the nursing career she loves. But her high hopes are dashed within an hour of arriving - the cabin is a dump, the roads are treacherous, and the local doctor wants nothing to do with her.

Annie Marlow has been through the worst. Rocked by tragedy, she heads to the one place that makes her happy: Oceanside in the Pacific Northwest, the destination of many family vacations when Annie was a teenager. Once there, Annie begins to restore her broken spirit, thanks, in part, to the folks she meets: a local painter, Keaton, whose large frame is equal to his big heart - and who helps Annie fix up her rental cottage by the sea; Mellie, the reclusive, prickly landlord Annie is determined to befriend; and Britt, a teenager with a terrible secret.

Nikki Burgess survived a terrible marriage and a worse divorce. She's just about given up hope of ever finding happiness. But when her ex-husband suddenly dies, she gets custody of her kids again - and a chance to start over. Dixie McPherson, on the other hand, has had way too much love. She has 11 tennis bracelets, dozens of trinkets, piles of sexy lingerie, and a tarnished reputation when all she ever wanted was true love, a partner, and a family. Carlisle Bartlett is loyal, kindhearted, and the funniest guy slinging drinks in the back of an airplane. But he has an ugly little secret. The only kind of love he's used to comes with bruises.

Clare Wilson is starting over. She's had it with her marriage to a charming serial cheater. Even her own son thinks she's given his father too many chances. With the support of her sisters, Maggie and Sarah, she's ready to move on. Facing her fortieth birthday, Clare is finally feeling the rush of unadulterated freedom. But when a near-fatal car accident lands Clare in the hospital, her life takes another detour. While recovering, Clare realizes she has the power to choose her life's path. With enthusiasm and a little envy, her sisters watch her bloom.