The women of the Cohen family are in crisis. Triggered by the death of their patriarch, Rudy, the glue that held them all together, everyone’s lives soon take a dramatic turn. Shelly, the younger of the two Cohen sisters, runs off to the West Coast to immerse herself in the emerging (and lucrative) world of technology. Her sister, Nancy, gets married at the age of twenty-one to a traveling salesman with a shadowy lifestyle, while their mother, Frieda, hurls herself into a boozy, troubled existence in Miami, trying to forget the past even as it haunts her.

A kid walks into your bookstore and says to you, Guess what? I'm your son. The one you put up for adoption seventeen years ago. The one you never told anyone about. Surprise! His name is Matthew Walker, and he's come to spend the summer on the Cape with his parents. Why? Well, he wants to meet you before he heads off to college in the fall. Tiny detail—he didn't tell his adoptive parents about his plan. And while you hoped this day would come someday, you're so stunned, you actually faint.

Former Blackhawk pilot Luke Angel wants nothing more than to enjoy the easy life he’s found in coastal Florida. He’s got a seaplane business, a well-trained dog, and a loyal and lovable crew to throw back margaritas with. But when a plane belonging to a friend goes missing from Luke’s airport, local detectives are understandably baffled. Clues are scattered from the Keys to the far side of the Gulf of Mexico, and Luke may be the only one with the connections to piece the puzzle back together.

Lark Smith has always had a plan for her life: find a fantastic guy, create a marriage as blissful as her parents’, pop out a couple of kids, and build a rewarding career as an oncologist. Things aren’t going so well. For one, the guy didn’t work out. Theoretically, she’d love to find someone else, but it hasn’t happened. Two, she’s just been transferred out of Oncology for being too emotional. (Is it her fault she’s a weeper?) Three, her parents just split up. Deviating from the plan was … well, not in the plan. A potential solution comes from the foul-tempered surgeon Lorenzo Santini.

Against the unforgiving landscape of a hospital, a group of terminally ill patients embraces the joys within their reach: friendship, freedom, rebellion. Each in their own way is broken; each in their own way is stronger for it. In the midst of pain and loss, they find community, even miracles, and together they are determined to reclaim from life what illness has taken from them. But a singular heartbreak has led one to swear off love forever. The risk of experiencing another tragedy feels too great.