In the late 1930s, civil war grips Spain. When General Franco and his Fascists succeed in overthrowing the government, hundreds of thousands are forced to flee in a treacherous journey over the mountains to the French border. Among them is Roser, a pregnant young widow, who finds her life intertwined with that of Victor Dalmau, an army doctor and the brother of her deceased love. In order to survive, the two must unite in a marriage neither of them desires.

The House of the Spirits brings to life the triumphs and tragedies of three generations of the Trueba family. The patriarch Esteban is a volatile, proud man whose voracious pursuit of political power is tempered only by his love for his delicate wife, Clara, a woman with a mystical connection to the spirit world. When their daughter, Blanca, embarks on a forbidden love affair in defiance of her implacable father, the result is an unexpected gift to Esteban.

Violeta comes into the world on a stormy day in 1920, the first girl in a family with five boisterous sons. From the start, her life is marked by extraordinary events, for the ripples of the Great War are still being felt, even as the Spanish flu arrives on the shores of her South American homeland almost at the moment of her birth.

Vienna, 1938. Samuel Adler is five years old when his father disappears during Kristallnacht—the night his family loses everything. As her child’s safety becomes ever harder to guarantee, Samuel’s mother secures a spot for him on a Kindertransport train out of Nazi-occupied Austria to England. He boards alone, carrying nothing but a change of clothes and his violin.

Though she was born into poverty, Inés Suárez, a seamstress in 16th-century Spain, embodies the same restless hope and opportunism that fuels her nation’s conquest of the Americas. Learning that her shiftless husband has vanished, Inés uses his disappearance to embark on her own adventure. It is a journey will lead her to Pedro de Valdivia - a conquistador who becomes the first royal governor of Chile - and to a love that not only changes her life but the course of history.