Deep in the heart of Appalachia stands a crooked farmhouse miles from any road. The Morrows keep to themselves, and it's served them well so far. When girls go missing off the side of the highway, the cops don't knock on their door. Which is a good thing, seeing what's buried in the Morrows' backyard. But 19-year-old Michael Morrow isn't like the rest of his family. He doesn't take pleasure in the screams that echo through the trees.

A group of close friends gathers at a secluded cabin in the wintry mountains of Colorado for a final holiday hurrah. Instead, it may be their last stand. First a massive blizzard leaves them marooned. Then the more chilling realization: Something is lurking in the woods, watching them, waiting.... Now a weekend of family, friends, and fun has turned into a test of love and loyalty in the face of inhuman horrors. The only hope for those huddled inside is to fight - tooth and nail, bullet and blade - for their lives. Otherwise, they’ll end up like the monsters’ other victims: bright pools of blood on glittering snow, screams lost in the vast mountains.

Joe works at a facility that performs human experimentation. His work just followed him home. The government wanted to unlock hidden abilities in the human mind. They put subjects in extreme sensory deprivation. All the test subjects went violently insane. But the research continued. Today it has been perfected. Almost perfected.

These people will give anything for the idols they worship, be they rock stars, actors or authors. Or even serial killers. Lori is just such a fanatic. Her obsession is with Edmund Cox, a man of sadistic cruelty who butchered more than 20 women. She’s gone so far as to forge a relationship with him, visiting him in prison and sending him letters on a regular basis. She will do anything to get close to him, so when he gives her a task, she eagerly accepts it. She has no idea of the horror that awaits her.

As a young, queer couple who flip houses, Charlie and Eve can’t believe the killer deal they’ve just gotten on an old house in a picturesque neighborhood. As they’re working in the house one day, there’s a knock on the door. A man stands there with his family, claiming to have lived there years before and asking if it would be alright if he showed his kids around. People pleaser to a fault, Eve lets them in. As soon as the strangers enter their home, uncanny and inexplicable things start happening.

Ana and Reid needed a lucky break. The horrifically complicated birth of their first child has left Ana paralyzed, bitter, and struggling: with mobility, with her relationship with Reid, with resentment for her baby. That's about to change with the words any New Yorker would love to hear—affordable housing lottery. They've won an apartment in the Deptford, one of Manhattan's most revered buildings. Reid dismisses disturbing events and Ana’s deep unease and paranoia as the price of living in New York—people are odd—but he can't explain the needle-like bite marks on the baby.

In a boarded-up house on a dead-end street at the edge of the wild Washington woods lives a family of three. A teenage girl who isn’t allowed outside, not after last time. A man who drinks alone in front of his TV, trying to ignore the gaps in his memory. And a house cat who loves napping and reading the Bible. An unspeakable secret binds them together, but when a new neighbor moves in next door, what is buried out among the birch trees may come back to haunt them all.

When Louise finds out her parents have died, she dreads going home. She doesn’t want to leave her daughter with her ex and fly to Charleston. She doesn’t want to deal with her family home, stuffed to the rafters with the remnants of her father’s academic career and her mother’s lifelong obsession with puppets and dolls. She doesn’t want to learn how to live without the two people who knew and loved her best in the world. Most of all, she doesn’t want to deal with her brother, Mark, who never left their hometown, gets fired from one job after another, and resents her success.

Mary is a quiet middle-aged woman doing her best to blend into the background. Unremarkable. Invisible. Unknown even to herself. But lately, things have been changing inside Mary. Along with the hot flashes and body aches, she can’t look in a mirror without passing out, and the voices in her head have been urging her to do unspeakable things. Fired from her job in New York, she moves back to her hometown hoping to reconnect with her past and inner self. What she finds instead are visions of terrifying mutilated specters that come with increasing regularity.

Episode Thirteen takes them to every ghost hunter's holy grail: the Paranormal Research Foundation. This brooding, derelict mansion holds secrets and clues about bizarre experiments that took place there in the 1970s. It's also famously haunted, and the team hopes their scientific techniques and high tech gear will prove it. But as the house begins to reveal itself to them, proof of an afterlife might not be everything Matt dreamed of.

A strange plague called the "Gets" is decimating humanity on a global scale. It causes people to forget - small things at first, like where they left their keys... then the not-so-small things like how to drive, or the letters of the alphabet. Then their bodies forget how to function involuntarily - and there is no cure. But now, far below the surface of the Pacific Ocean, deep in the Marianas Trench, an heretofore unknown substance hailed as "ambrosia" has been discovered - a universal healer, from initial reports.

"Mom seems off." Her brother's words echo in Sam Montgomery's ear as she turns onto the quiet North Carolina street where their mother lives alone. She brushes the thought away as she climbs the front steps. Sam's excited for this rare extended visit, and looking forward to nights with just the two of them, drinking boxed wine, watching murder mystery shows, and guessing who the killer is long before the characters figure it out. But stepping inside, she quickly realizes home isn’t what it used to be.

Lifestyle journalist Katrine escaped past traumas by moving to a coast renowned for seaside holidays and natural beauty. But when a vast hoard of human remains and prehistoric artifacts is discovered in nearby Brickburgh, a hideous shadow engulfs her life. Helene, a disillusioned lone parent, lost her brother, Lincoln, six years ago. Disturbing subterranean noises he recorded prior to vanishing, draw her to Brickburgh's caves. A site where early humans butchered each other across 60,000 years. Upon the walls, images of their nameless gods remain.

Young Jude Brighton has been missing for three days, and while the search for him is in full swing in the small town of Deer Valley, Oregon, the locals are starting to lose hope. They're well aware that the first 48 hours are critical and after that, the odds usually point to a worst-case scenario. And despite Stevie Clark's youth, he knows that, too; he's seen the cop shows. He knows what each ticking moment may mean for Jude, his cousin and best friend.

Now reduced to a schoolyard chant, the Hope family murders shocked the Maine coast one bloody night in 1929. While most people assume seventeen-year-old Lenora was responsible, the police were never able to prove it. Other than her denial after the killings, she has never spoken publicly about that night, nor has she set foot outside Hope’s End, the cliffside mansion where the massacre occurred. It’s now 1983, and home-health aide Kit McDeere arrives at a decaying Hope’s End to care for Lenora after her previous nurse fled in the middle of the night.