1975 is a time of change in America. The Vietnam War is ending. Muhammad Ali is fighting Joe Frazier. And in the small town of Monta Clare, Missouri, girls are disappearing. When the daughter of a wealthy family is targeted, the most unlikely hero emerges—Patch, a local boy, who saves the girl, and, in doing so, leaves heartache in his wake. Patch and those who love him soon discover that the line between triumph and tragedy has never been finer. And that their search for answers will lead them to truths that could mean losing one another.

Eighty-one-year-old widow Maggie Burkhardt came to the Royal Karnak to escape. But not in quite the same way as most other guests who are relaxing at this hotel on the banks of the Nile. Maggie, a compulsive fixer of other people’s lives, may have found herself in hot water at her last hotel in Switzerland and just might have needed to get out of there fast. But here at the Royal Karnak, under the hot Saharan sun, she has a comfortable suite, a loyal confidante in the hotel manager, Ahmed, and a handful of sympathetic friends. One morning, however, Maggie notices a new arrival at check-in.

In a Philadelphia neighborhood rocked by the opioid crisis, two once-inseparable sisters find themselves at odds. One, Kacey, lives on the streets in the vise of addiction. The other, Mickey, walks those same blocks on her police beat. They don't speak anymore, but Mickey never stops worrying about her sibling. Then Kacey disappears, suddenly, at the same time that a mysterious string of murders begins in Mickey's district, and Mickey becomes dangerously obsessed with finding the culprit - and her sister - before it's too late.

It’s a beautiful day in Newport, Rhode Island, when Phoebe Stone arrives at the grand Cornwall Inn wearing a green dress and gold heels, not a bag in sight, alone. She's immediately mistaken by everyone in the lobby for one of the wedding people, but she’s actually the only guest at the Cornwall who isn’t here for the big event. Phoebe is here because she’s dreamed of coming for years—she hoped to shuck oysters and take sunset sails with her husband, only now she’s here without him, at rock bottom, and determined to have one last decadent splurge on herself.

Washington, DC, 1950. Everyone keeps to themselves at Briarwood House, a down-at-the-heels all-female boardinghouse in the heart of the nation’s capital where secrets hide behind white picket fences. But when the lovely, mysterious widow Grace March moves into the attic room, she draws her oddball collection of neighbors into unlikely friendship. Grace’s weekly attic-room dinner parties and window-brewed sun tea become a healing balm on all their lives, but she hides a terrible secret of her own.

After Lucy is found wandering the streets, covered in her best friend Savvy’s blood, everyone thinks she is a murderer. Lucy and Savvy were the golden girls of their small Texas town: pretty, smart, and enviable. Lucy married a dream guy with a big ring and an even bigger new home. Savvy was the social butterfly loved by all, and if you believe the rumors, especially popular with the men in town. It’s been years since that horrible night, a night Lucy can’t remember anything about, and she has since moved to LA and started a new life.

The plane is jam-packed. Every seat is taken. So of course the flight is delayed! Flight attendant Allegra Patel likes her job—she’s generally happy with her life, even if she can’t figure out why she hooks up with a man she barely speaks to—but today is her twenty-eighth birthday. She can think of plenty of things she’d rather be doing than placating a bunch of grumpy passengers.

Steve Wheeler is enjoying retired life. He still does the odd bit of investigation work, but he prefers his familiar routines: the pub quiz, his favorite bench, his cat waiting for him at home. His days of adventure are over. Adrenaline is daughter-in-law Amy’s job now. Amy Wheeler thinks adrenaline is good for the soul. Working in private security, every day is dangerous. She’s currently on a remote island protecting mega-bestselling author Rosie D’Antonio, until a dead body and a bag of money mean trouble in paradise. So she sends an SOS to the only person she trusts . . .

The identity comes first: Evie Porter. Once she’s given a name and location by her mysterious boss, Mr. Smith, she learns everything there is to know about the town and the people in it. Then the mark: Ryan Sumner. The last piece of the puzzle is the job. Evie isn’t privy to Mr. Smith’s real identity, but she knows this job isn't like the others. Ryan has gotten under her skin, and she’s starting to envision a different sort of life for herself. But Evie can’t make any mistakes—especially after what happened last time.

Forrmer academic Arthur Opp weighs 550 pounds and hasn’t left his rambling Brooklyn home in a decade. Twenty miles away in Yonkers, seventeen-year-old Kel Keller navigates life as the poor kid in a rich school and pins his hopes on what seems like a promising baseball career - if he can untangle himself from his family drama.

When the enslaved Jim overhears that he is about to be sold to a man in New Orleans, separated from his wife and daughter forever, he decides to hide on nearby Jackson Island until he can formulate a plan. Meanwhile, Huck Finn has faked his own death to escape his violent father, recently returned to town. As all readers of American literature know, thus begins the dangerous and transcendent journey by raft down the Mississippi River toward the elusive and too-often-unreliable promise of the Free States and beyond.

Maine, 1789: When the Kennebec River freezes, entombing a man in the ice, Martha Ballard is summoned to examine the body and determine cause of death. As a midwife and healer, she is privy to much of what goes on behind closed doors in Hallowell. Her diary is a record of every birth and death, crime and debacle that unfolds in the close-knit community. Months earlier, Martha documented the details of an alleged rape committed by two of the town’s most respected gentlemen—one of whom has now been found dead in the ice.

Now reduced to a schoolyard chant, the Hope family murders shocked the Maine coast one bloody night in 1929. While most people assume seventeen-year-old Lenora was responsible, the police were never able to prove it. Other than her denial after the killings, she has never spoken publicly about that night, nor has she set foot outside Hope’s End, the cliffside mansion where the massacre occurred. It’s now 1983, and home-health aide Kit McDeere arrives at a decaying Hope’s End to care for Lenora after her previous nurse fled in the middle of the night.

The three Blue sisters are exceptional—and exceptionally different. Avery, the eldest and a recovering heroin addict turned strait-laced lawyer, lives with her wife in London; Bonnie, a former boxer, works as a bouncer in Los Angeles following a devastating defeat; and Lucky, the youngest, models in Paris while trying to outrun her hard-partying ways. They also had a fourth sister, Nicky, whose unexpected death left the family reeling. A year later, as they each navigate grief, addiction and ambition, they find they must return to New York to stop the sale of the apartment they were raised in.

In 1950s Tehran, seven-year-old Ellie lives in grand comfort until the untimely death of her father, forcing Ellie and her mother to move to a tiny home downtown. Lonely and bearing the brunt of her mother’s endless grievances, Ellie dreams of a friend to alleviate her isolation. Luckily, on the first day of school, she meets Homa, a kind, passionate girl with a brave and irrepressible spirit. Together, the two girls play games, learn to cook in the stone kitchen of Homa’s warm home, wander through the colorful stalls of the Grand Bazaar, and share their ambitions for becoming “lion women.”