Located in a nameless desert somewhere in the great American Southwest, Night Vale is a small town where ghosts, angels, aliens, and government conspiracies are all commonplace parts of everyday life. It is here that the lives of two women, with two mysteries, will converge.

Nilanjana Sikdar is an outsider to the town of Night Vale. Working for Carlos, the town's top scientist, she relies on fact and logic as her guiding principles. But all of that is put into question when Carlos gives her a special assignment investigating a mysterious rumbling in the desert wasteland outside of town. This investigation leads her to the Joyous Congregation of the Smiling God and to Darryl, one of its most committed members.

Keisha Lewis lived a quiet life with her wife, Alice, until the day Alice disappeared. After months of searching, presuming she was dead, Keisha held a funeral, mourned, and gradually tried to get on with her life. But that was before Keisha started to see her wife, again and again, in the background of news reports from all over America. Alice isn't dead, and she is showing up at every major tragedy and accident in the country. Following a line of clues, Keisha takes a job as a long-haul truck driver and begins searching for Alice.

Born at the end of the old world, Miriam grows up during The Great Reckoning, a sprawling, decades-long war that nearly decimates humanity and strips her of friends and family. Devastated by grief and loneliness, she emotionally exiles herself, avoiding relationships or allegiances, and throws herself into her work - disengagement that serves her when the war finally ends, and The New Society arises.

This is not a fairy tale. This is about real witches. Grandmamma loves to tell about witches. Real witches are the most dangerous of all living creatures on Earth. There's nothing they hate so much as children, and they work all kinds of terrifying spells to get rid of them. Her grandson listens closely to Grandmamma's stories - but nothing can prepare him for the day he comes face-to-face with The Grand High Witch herself!