In retreat from a devastating loss and crushing injustice, Katie lives alone in a fortresslike stone house on Jacob’s Ladder island. Once a rising star in the art world, she finds refuge in her painting. The neighboring island of Ringrock houses a secret: a government research facility. And now two agents have arrived on Jacob’s Ladder in search of someone—or something—they refuse to identify. Although an air of menace hangs over these men, an infinitely greater threat has arrived, one so strange even the island animals are in a state of high alarm.

Bartholomew Lampion is born on a day of tragedy and terror that will mark his family forever. All agree that his unusual eyes are the most beautiful they have ever seen. On this same day, a thousand miles away, a ruthless man learns that he has a mortal enemy named Bartholomew. He embarks on a relentless search to find this enemy, a search that will consume his life. And a girl is born from a brutal rape, her destiny mysteriously linked to Barty and the man who stalks him.

Barton Dawes' unremarkable but comfortable existence suddenly takes a turn for the worst. A new highway extension is being built right over the laundry plant where he works - and right over his home. Dawes isn't the sort of man who will take an insult of this magnitude lying down. His steadfast determination to fight the inevitable course of progress drives his wife and friends away while he tries to face down the uncaring bureaucracy that has destroyed his life.

Bill Wile is an easygoing, hardworking guy who leads a quiet, ordinary life. But that is about to change. One evening, after his usual eight-hour bartending shift, he finds a typewritten note under the windshield wiper of his car. If you don’t take this note to the police and get them involved, I will kill a lovely blond schoolteacher. If you do take this note to the police, I will instead kill an elderly woman active in charity work. You have four hours to decide. The choice is yours.

They're out there...waiting...watching. Unseen by normal eyes, but all too visible to Slim MacKenzie, a young man blessed - or cursed - by Twilight Eyes.