Lincoln Rhyme was once a brilliant criminologist, a genius in the field of forensics - until an accident left him physically and emotionally shattered. But now a diabolical killer is challenging Rhyme to a terrifying and ingenious duel of wits. With police detective Amelia Sachs by his side, Rhyme must follow a labyrinth of clues that reaches back to a dark chapter in New York City’s past - and reach further into the darkness of the mind of a madman who won’t stop until he has stripped life down to the bone.

Colter Shaw is a career "reward-seeker", making his living traveling the country and locating missing persons, collecting reward money in return. So it is not unusual when a wealthy entrepreneur hires him to track down his wife, an enigmatic artist who vanished one month before. As Shaw begins to investigate, he suspects that she was fleeing a bad marriage, and he follows her trail to an artists' retreat in Indiana. The case takes one surprising turn after another, and soon, Shaw begins to wonder if this mysterious woman is more of a captor than a captive.

Alex Cross is a homicide detective with a Ph.D. in psychology. He works and lives in Southeast D.C. and looks like Muhammad Ali in his prime. He's a tough guy from a tough part of town who wears Harris Tweed jackets and likes to relax by banging out Gershwin tunes on his baby grand piano. But he also has two adorable kids of his own, and they are his own special vulnerabilities.

Dr. Morton Handler practiced a strange brand of psychiatry. Among his specialties were fraud, extortion, and sexual manipulation. Handler paid for his sins when he was brutally murdered in his luxurious Pacific Palisades apartment. The police have no leads, but they do have one possible witness: seven-year-old Melody Quinn.

By age twenty-four, Letty Davenport has seen more action and uncovered more secrets than many law enforcement professionals. Now a recent Stanford grad with a master’s in economics, she’s restless and bored in a desk job for U.S. Senator Colles. Letty’s ready to quit, but her skills have impressed Colles, and he offers her a carrot: feet-on-the-ground investigative work, in conjunction with the Department of Homeland Security.