Women can be heroes. When twenty-year-old nursing student Frances “Frankie” McGrath hears these words, it is a revelation. Raised in the sun-drenched, idyllic world of Southern California and sheltered by her conservative parents, she has always prided herself on doing the right thing. But in 1965, the world is changing, and she suddenly dares to imagine a different future for herself. When her brother ships out to serve in Vietnam, she joins the Army Nurse Corps and follows his path.

Texas, 1921. A time of abundance. The Great War is over, the bounty of the land is plentiful, and America is on the brink of a new and optimistic era. But for Elsa Wolcott, deemed too old to marry in a time when marriage is a woman’s only option, the future seems bleak. Until the night she meets Rafe Martinelli. By 1934, the world has changed; millions are out of work and drought has devastated the Great Plains. Elsa must make an agonizing choice: fight for the land she loves or leave it behind and go west, to California, in search of a better life for her family.

Ernt Allbright, a former POW, comes home from the Vietnam war a changed and volatile man. When he loses yet another job, he makes an impulsive decision: He will move his family north, to Alaska, where they will live off the grid in America’s last true frontier.

Like many couples, Michael and Jolene Zarkades have to face the pressures of everyday life—children, careers, bills, chores—even as their twelve-year marriage is falling apart. Then a deployment sends Jolene deep into harm's way and leaves defense attorney Michael at home, unaccustomed to being a single parent to their two girls. As a mother, it agonizes Jolene to leave her family, but as a solider, she has always understood the true meaning of duty. In her letters home, she paints a rose-colored version of her life on the front lines, shielding her family from the truth.

Celebrating her forty-fifth birthday at her local pub, popular podcaster Alix Summer crosses paths with an unassuming woman called Josie Fair. Josie, it turns out, is also celebrating her forty-fifth birthday. They are, in fact, birthday twins. A few days later, Alix and Josie bump into each other again, this time outside Alix’s children’s school. Josie has been listening to Alix’s podcasts and thinks she might be an interesting subject for her series. She is, she tells Alix, on the cusp of great changes in her life.