The Ultimates - the first government-sponsored cadre of super heroes - was assembled to face threats to humanity too insanely powerful for other operatives to handle. But even the Ultimates are unprepared for a quintet of mysterious visitors who appear in the midst of the team's top-security base of operations, claiming to be emissaries from the future. These "Tomorrow Men" say Earth's civilization are at a crossroads - on the verge of enslavement by a secret, immensely efficient organization known in the future as Tiber.

Born to a rarified breed of Russian aristocracy, Kraven the Hunter had stalked and killed every animal known to man and considered himself the world's best big-game hunter. It was this confidence that brought him to New York years ago, in an obsessive quest to hunt what he considered the city's greatest prey: Spider-Man. But his target eluded him time and again, mocking him at every turn.

Cyclops and Emma Frost re-form the team with the express purpose of "astonishing" the world. But when breaking news regarding the mutant gene unexpectedly hits the airwaves, will it derail their new plans before they even get started? As demand for the "mutant cure" reaches near-riot levels, the X-Men go head-to-head with the enigmatic Ord, with an unexpected ally - and some unexpected adversaries - tipping the scales!

Hydra has a synthetic pathogen that will make the entire human race dependent on them for the cure. A.I.M.'s newly developed nanotech compound to enslave humanity is dangerously close to contaminating the world's water supplies. Ultron is poised on the edge of Singularity, Earth's technology at his metallic fingertips. Dormammu has a plan to save the world - by claiming it as his own. The High Evolutionary is rewriting the human genome in a bid to turn humankind into a eugenic slave-race. Everybody wants to rule the world - and only the isolated Avengers can stop them.

Under secret orders to assassinate the Widow, Hawkeye, the rough-edged marksman, finds himself caught up in a violent prison break that releases some of the world's most vicious and powerful criminals. Defying his superiors, Hawkeye joins forces with the sultry Russian spy and a mismatched group of personalities that include Spider-Man, Spider-Woman, Luke Cage, Captain America, and Iron Man.