On the day she was abducted, Annie O’Sullivan, a 32-year-old Realtor, had three goals: sell a house, forget about a recent argument with her mother, and be on time for dinner with her ever-patient boyfriend. The open house is slow, but when her last visitor pulls up in a van as she’s about to leave, Annie thinks it just might be her lucky day after all.

In the lockdown ward of a psychiatric hospital, Dr. Nadine Lavoie is in her element. She has the tools to help people, and she has the desire: Healing broken families is what she lives for. But Nadine doesn’t want to look too closely at her own past because there are whole chunks of her life that are black holes. It takes all her willpower to tamp down her recurrent claustrophobia, and her daughter, Lisa, is a runaway who has been on the streets for seven years. When a distraught woman, Heather Simeon, is brought into the Psychiatric Intensive Care Unit after a suicide attempt, Nadine gently coaxes her story out of her - and learns of some troubling parallels to her own life.

The Cold Creek Highway stretches close to five hundred miles through British Columbia’s rugged wilderness to the west coast. Isolated and vast, it has become a prime hunting ground for predators. For decades, young women traveling the road have gone missing. Motorists and hitchhikers, those passing through or living in one of the small towns scattered along the region, have fallen prey time and again. And no killer or abductor who has stalked the highway has ever been brought to justice.

Eleven years ago, Lindsey Nash escaped into the night with her young daughter and left an abusive relationship. Her ex-husband, Andrew, was sent to jail and Lindsey started over with a new life. Now, Lindsey is older and wiser, with her own business and a teenage daughter who needs her more than ever. When Andrew is finally released from prison, Lindsey believes she has cut all ties and left the past behind her. But she gets the sense that someone is watching her, tracking her every move.

Toni Murphy was eighteen when she and her boyfriend, Ryan, were wrongly convicted of the murder of her younger sister. Now she is thirty-four and back in her hometown, working every day to forge and adjust to a new life on the outside. She's doing everything in her power to avoid violating her parole and going back to prison. But nothing is making that easy – not Ryan, who is convinced he can figure out the truth; not her mother, who clearly doubts Toni's innocence; and certainly not the group of women who made Toni's life miserable in high school.

The people who call End of the Line need hope. They need reassurance that life is worth living. But some are unlucky enough to get through to Laura. Laura doesn’t want them to hope. She wants them to die. Laura hasn’t had it easy: she's survived sickness and a difficult marriage only to find herself heading for forty, unsettled and angry. She doesn't love talking to people worse off than she is. She craves it. But now someone’s on to her - Ryan, whose world falls apart when his pregnant wife ends her life, hand in hand with a stranger.

After the loss of a child along with a slew of agonizing misfortunes, Nick and Jess decide to end their lives. Unable to cope with the misery that fills their days, they commit one last act together and die in loving relief. But when Nick wakes up, he soon realizes that death isn't the gentle darkness he expected. Panicked and horrified, he struggles to understand the twisted abominations and hellish world he's now trapped in.

Ignorant of civilization and cautioned against its evils, nineteen-year-old Wren and her two sisters, Sage and Evie, were raised in off-the-grid isolation in a primitive cabin in upstate New York. When the youngest grows gravely ill, their mother leaves with the child to get help from a nearby town. And they never return. As months pass, hope vanishes. Supplies are low. Livestock are dying.

He is her husband. She is his captive. Her husband calls her Jane. That is not her name. She lives in a small farm cottage, surrounded by vast, open fields. Everywhere she looks, there is space. But she is trapped. No one knows she is there. Visitors rarely come to the farm; if they do, she is never seen.

All her life, Sara Gallagher has wondered about her birth parents. As an adopted child with two sisters who were born naturally to her parents, Sara did not have an ideal home life. The question of why she was given up for adoption has always haunted her. Finally, she is ready to take steps and to find closure. But some questions are better left unanswered.

Perla Wultz lives with her husband, Grant, and their precious daughter, Sophie, in a gated Pasadena community. Affluent, sociable, and accomplished, Perla plays the part of loving wife and mother to perfection. It seems an ideal life, if not for a decades-old crime that has become Perla’s dark and consuming secret obsession. Twenty-three years ago, Leewood Folcrum confessed to murdering two young girls during a birthday party. Though he’s been condemned to a life sentence, his crime is not forgotten.

Haunted by the serial killer she never caught, Detective Kimberley King leaves her job in New York and relocates to the sleepy town of Dead Woman Crossing, Oklahoma. Kimberley hopes to bring her daughter Jessica up close to her family, far from the bad memories the city holds. But her quiet new home is not the peaceful place she dreamed of. Within days of her arrival, Kimberley is called to the scene of a terrible crime: her friend Hannah, a single mother, has been brutally murdered while her one-year-old daughter was sleeping nearby.

While in college in upstate New York, Shay Evans and her best friends met a captivating man who seduced them with a web of lies about the way the world works, bringing them under his thrall. By senior year, Shay and her friend Laurel were the only ones who managed to escape. Now, eight years later, Shay’s built a new life in a tony Texas suburb. But when she hears the horrifying news of Laurel’s death―delivered, of all ways, by her favorite true-crime podcast crusader―she begins to suspect that the past she thought she buried is still very much alive.

When she was 9 years old, Melody Browne's house burned down, and it took all of her childhood memories with it. Now she's a single mother of a teenage boy living in Central London. She hasn't seen her parents since she left home at 15, but she doesn't mind. She's better off on her own. She works as a dinner lady at her son's school and has no idea where her humdrum life is heading. But one summer's night, a hypnotist inadvertently unlocks memories of her childhood, and her whole life is turned upside down.

Lisa, a single mother, devotes herself to raising her 16-year-old daughter, Ava. She doesn’t speak of her past or Ava’s absent father. Ava is getting tired of her overprotective mother. She wants to live like a normal teenager. As her life begins to unravel, Lisa knows that the only way she can protect herself and her daughter is to face her fears. Yet courage won’t be enough. She’ll need help from the only person she can trust - her best friend, Marilyn. Between them, they have to save Ava, and to do that, they have to be honest with each other.