On the surface, these seven women are as different as can be - but each has had her share of bad luck, from cheating husbands to sexist colleagues to a legal system that often doesn't do its job. Now, drawn together by tragedy, they're forging a bond that will help them right the wrongs committed against them and discover an inner strength they didn't know they had. The Sisterhood is learning that when bad things happen, you can roll over and play dead...or you can get up fighting...

It came out of the blue. A half-million dollars on graduation day. For Annie Daisy Clark, it was the capital she needed to start a business. Vowing to pay back every penny of it one day, she kept the bag of cash she’d found, and never looked back. Ten years later, Annie’s investment has paid off. The owner of a successful chain of elegant coffee bars, she is blissfully engaged and about to return to Boston for her ten-year college reunion. She also begins making good on her promise. But just as Annie’s life seems complete, the dark history of the money returns to haunt her.

Luna Bodman always looks forward to a new shipment of furniture at the restoration shop. Her brother, Cullen, has a knack for finding discarded pieces with an intriguing history, and Luna likes to sit with each item to see if she can feel any kind of vibrations. Usually, Cullen does his thing while Luna does hers, but the arrival of an old armoire triggers a reaction in Luna that’s impossible to ignore. From the moment Luna wiggles inside the armoire and closes her eyes, she feels an overpowering and disturbing sensation.

When Samantha Rainford - newly wed to Douglas Cosmo Rainford III - returns home from her honeymoon to find divorce papers waiting, she's shocked and heartbroken. Then she discovers that she's not the first to be abandoned - she's one of four (or maybe more) ex-Mrs. Rainfords - and decides it's time to put into practice that old truism: Don't get mad, get even.

For Melanie Drake, school guidance counselor in a small Virginia town, the day’s challenges typically involve a playground scuffle or a student skipping school. It’s worlds away from her previous career as a vital part of the Office of Special Investigations. There, she devoted herself heart and soul to covert operations, the riskier the better.