At the end of the Second World War, Cyril Conroy combines luck and a single canny investment to begin an enormous real estate empire, propelling his family from poverty to enormous wealth. His first order of business is to buy the Dutch House, a lavish estate in the suburbs outside of Philadelphia. Meant as a surprise for his wife, the house sets in motion the undoing of everyone he loves. The story is told by Cyril’s son Danny, as he and his older sister, the brilliantly acerbic and self-assured Maeve, are exiled from the house where they grew up by their stepmother.

Women can be heroes. When twenty-year-old nursing student Frances “Frankie” McGrath hears these words, it is a revelation. Raised in the sun-drenched, idyllic world of Southern California and sheltered by her conservative parents, she has always prided herself on doing the right thing. But in 1965, the world is changing, and she suddenly dares to imagine a different future for herself. When her brother ships out to serve in Vietnam, she joins the Army Nurse Corps and follows his path.

Spanning the years 1900 to 1977, The Covenant of Water is set in Kerala, on South India’s Malabar Coast, and follows three generations of a family that suffers a peculiar affliction: in every generation, at least one person dies by drowning—and in Kerala, water is everywhere. At the turn of the century, a twelve-year-old girl from Kerala’s long-existing Christian community, grieving the death of her father, is sent by boat to her wedding, where she will meet her forty-year-old husband for the first time.

After Tova Sullivan’s husband died, she began working the night shift at the Sowell Bay Aquarium, mopping floors and tidying up. Keeping busy has always helped her cope, which she’s been doing since her eighteen-year-old son, Erik, mysteriously vanished on a boat in Puget Sound over thirty years ago. Tova becomes acquainted with curmudgeonly Marcellus, a giant Pacific octopus living at the aquarium. Marcellus knows more than anyone can imagine but wouldn’t dream of lifting one of his eight arms for his human captors—until he forms a remarkable friendship with Tova.

Is it possible to write a sidesplitting novel about the breakup of the perfect marriage? If the writer is Nora Ephron, the answer is a resounding yes. For in this inspired confection of adultery, revenge, group therapy, and pot roast, the creator of Sleepless in Seattle reminds us that comedy depends on anguish as surely as a proper gravy depends on flour and butter.

Research scientist Dr. Marina Singh is sent to Brazil to track down her former mentor, Dr. Annick Swenson, who seems to have disappeared in the Amazon while working on an extremely valuable new drug. The last person who was sent to find her died before he could complete his mission. Plagued by trepidation, Marina embarks on an odyssey into the insect-infested jungle in hopes of finding answers to the questions about her friend's death, her company's future, and her own past.

William Waters grew up in a house silenced by tragedy, where his parents could hardly bear to look at him, much less love him—so when he meets the spirited and ambitious Julia Padavano in his freshman year of college, it’s as if the world has lit up around him. With Julia comes her family, as she and her three sisters are inseparable: Sylvie, the family’s dreamer, is happiest with her nose in a book; Cecelia is a free-spirited artist; and Emeline patiently takes care of them all.

Chemist Elizabeth Zott is not your average woman. In fact, Elizabeth Zott would be the first to point out that there is no such thing as an average woman. But it’s the early 1960s and her all-male team at Hastings Research Institute takes a very unscientific view of equality. Except for one: Calvin Evans; the lonely, brilliant, Nobel–prize nominated grudge-holder who falls in love with—of all things—her mind. True chemistry results.

Washington, DC, 1950. Everyone keeps to themselves at Briarwood House, a down-at-the-heels all-female boardinghouse in the heart of the nation’s capital where secrets hide behind white picket fences. But when the lovely, mysterious widow Grace March moves into the attic room, she draws her oddball collection of neighbors into unlikely friendship. Grace’s weekly attic-room dinner parties and window-brewed sun tea become a healing balm on all their lives, but she hides a terrible secret of her own.

Celebrating her forty-fifth birthday at her local pub, popular podcaster Alix Summer crosses paths with an unassuming woman called Josie Fair. Josie, it turns out, is also celebrating her forty-fifth birthday. They are, in fact, birthday twins. A few days later, Alix and Josie bump into each other again, this time outside Alix’s children’s school. Josie has been listening to Alix’s podcasts and thinks she might be an interesting subject for her series. She is, she tells Alix, on the cusp of great changes in her life.

Authors June Hayward and Athena Liu were supposed to be twin rising stars: same year at Yale, same debut year in publishing. But Athena’s a cross-genre literary darling, and June didn’t even get a paperback release. Nobody wants stories about basic white girls, June thinks. So when June witnesses Athena’s death in a freak accident, she acts on impulse: she steals Athena’s just-finished masterpiece, an experimental novel about the unsung contributions of Chinese laborers to the British and French war efforts during World War I.

Millions of Amor Towles fans are in for a treat as he shares some of his shorter fiction: six stories based in New York City and a novella set in Golden Age Hollywood. The New York stories, most of which take place around the year 2000, consider the fateful consequences that can spring from brief encounters and the delicate mechanics of compromise that operate at the heart of modern marriages.

Marion and Shiva Stone are twin brothers born of a secret union between a beautiful Indian nun and a brash British surgeon. Orphaned by their mother’s death and their father’s disappearance, bound together by a preternatural connection and a shared fascination with medicine, the twins come of age as Ethiopia hovers on the brink of revolution.

Sam and Sadie—two college friends, often in love, but never lovers—become creative partners in a dazzling and intricately imagined world of video game design, where success brings them fame, joy, tragedy, duplicity, and, ultimately, a kind of immortality. It is a love story, but not one you have heard before.

The plane is jam-packed. Every seat is taken. So of course the flight is delayed! Flight attendant Allegra Patel likes her job—she’s generally happy with her life, even if she can’t figure out why she hooks up with a man she barely speaks to—but today is her twenty-eighth birthday. She can think of plenty of things she’d rather be doing than placating a bunch of grumpy passengers.