While visiting Japan, Wolverine is recruited to recover a stolen experimental drug, one that has the potential to be a true miracle cure for all human disease - or a sadistic means of enslaving the world. With every hour bringing mankind closer to tragedy, he embarks on a daring mission to identify the thieves and thwart their terrifying agenda.

This exciting new anthology has over a dozen original tales starring the vicious foes of Marvel's superheroes: Greg Cox's chronicle of the Super-Skrull's conflict with the Avengers, Michael Jan Friendman's story of evil Loki's latest attempt to snare his stepbrother Thor, Adam-Troy Castro's tale of a mutant who brings Magneto and X-Men's Professor X together in a unique manner, Glenn Greenberg's pairing of Venom and the Absorbing Man in an unlikely jailbreak.

In a Manhattan warehouse, an innocent man has been murdered during a mysterious crime. Evidence points to the involvement of Venom - the alien symbiote obsessed with Spider-Man's destruction. Yet Venom has always safeguarded innocent lives. Has Venom gone completely around the bend, or is there another suspect? Spider-Man thinks there is more to the crime than meets the eye. The specter of the Hobgoblin, one of Spider-Man's nastiest foes, falls on a series of thefts and leads the web-slinger to a deadly secret that may cause New York's destruction.

A vicious serial killer named Cletus Kasady has had his body chemistry altered by an alien creature. Now, Kasady can transform into Carnage, who, along with his lethal living costume, lives for chaos and random acts of senseless, brutal murder! Carnage has been returned to New York in chains, the subject of a daring attempt to reverse the effects of his metamorphosis. When the interference of a deranged scientist causes the experiment to go horribly wrong, Carnage is set loose upon the city once again!

No evildoers have tried to flatten Peter Parker in weeks. His marriage to Mary Jane is stronger than ever, and he's enjoying his job as a high-school science teacher. Life is good. Naturally, that doesn't last. When Peter learns that his old enemy, the Rhino, is on a rampage in Times Square, he suits up as Spider-Man to stop the destructive villain in his tracks. But he's unexpectedly foiled in his attempts by the Black Cat, a former ally and old flame. The Cat informs Peter that the Rhino is just a distraction - the real threat comes from a group of Ancients.