I’ve touched on the topic of endotoxemia in past episodes of the Defiant Health podcast. In this episode, let’s dive deeper into this topic that is absolutely crucial to understanding and managing SO many aspects of health, from subduing anxiety and panic, to depressive, to joint pain and skin rashes, to gastrointestinal conditions, even weight management.

What is endotoxemia? Fecal microbes, so-called Gram-negative species because of the way these microbes take up stain for examination under a microscope, species such as E. coli and Salmonella, have something called lipopolysaccharide endotoxin in their cells walls. Other species, so-called Gram positive species such as Enterococcus, Staphylococcus, and Streptococcus, that stain in a different manner, have something called lipoteichoic acid in their cell walls. When these microbes die, both Gram-negative and Gram-positive, these toxic factors are released into the intestines. If these fecal microbes are confined to the colon, where they belong, a section of GI tract adapted to their presence, the entry of these toxic components are limited and current evidence is unclear in how importat this process is. The real trouble occurs, however, when fecal microbes have invaded the 24-feet of small intestine, a process we label small intetinal bacterial overgrowth, or SIBO, because the small intestine—the stomach, duodenum, jejunum, and ileum are not well-adapted to the invasion of fecal species. Here, they die, release their toxic components, which then enter the bloodstream, the process labeled endotoxemia. People with SIBO therefore have high blood levels, typically 200-400% higher, levels of endotoxin. This is how microbes in the GI Tract export their effects to all other parts of the body. So let’s discuss this process and how you can take control over it to be be better able to take control over your emotions, mood, sleep, energy, weight, and numerous other aspects of health.

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For BiotiQuest probiotics including Sugar Shift, go here.

A 15% discount is available for Defiant Health podcast listeners by entering discount code UNDOC15 (case-sensitive) at checkout.*
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Get your 15% Paleovalley discount on fermented grass-fed beef sticks, Bone Broth Collagen, low-carb snack bars and other high-quality organic foods here.*

For 12% off every order of grass-fed and pasture-raised meats from Wild Pastures, go here.
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MyReu

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Books:

Super Gut: The 4-Week Plan to Reprogram Your Microbiome, Restore Health, and Lose Weight

Wheat Belly: Lose the Wheat, Lose the Weight and Find Your Path Back to Health; revised & expanded ed

I’ve been showing thousands of people how to restore this microbe lost by the majority of modern people, Lactobacillus reuteri. But, of all the spectacular improvements in health we can gain by managing our microbiomes, such as an increase in empathy and generosity, reduction in anxiety and depression, deeper sleep, increased libido, restored youthful musculature and strength, the females in my audience have repeatedly said something like, “Well, that’s all well and good, but I’m mostly interested in the skin benefits.” So I’ve spent a good deal of time, energy, and resources in exploring this question, including performing a small human clinical trial to better understand how and why restoration of L. reuteri, especially when combined with other non-microbial synergistic factors, can restore youthful healthy skin.

One issue that has emerged to the forefront in our quest to better under skin health and appearance is the issue of skin pH. We may not think about skin this way, but healthy skin is acidic. The pH of healthy skin in someone not plagued by eczema, acne, rosacea, psoriasis, or other skin conditions is typically around 4.5. Recall that neutral is 7.0 and the blood is mildly alkaline at a pH of 7.4. Unhealthy skin, in contrast, skin with various skin rashes, has a pH of around 5.5—given the logarithmic nature of the pH scale, unhealthy skin is therefore 10-fold less acidic than healthy skin, a huge difference. This difference in pH is a crucial determinant of what you skin looks and feels like, whether you will be prone to these sorts of skin rashes or whether you can enjoy smooth youthful skin. So let’s dive into that topic, the importance of managing skin pH.

_______________________________________________________________________________

For BiotiQuest probiotics including Sugar Shift, go here.

A 15% discount is available for Defiant Health podcast listeners by entering discount code UNDOC15 (case-sensitive) at checkout.*
_________________________________________________________________________________

Get your 15% Paleovalley discount on fermented grass-fed beef sticks, Bone Broth Collagen, low-carb snack bars and other high-quality organic foods here.*

For 12% off every order of grass-fed and pasture-raised meats from Wild Pastures, go here.
_____________________________________________________________________________

MyReuteri and Gut to Glow can be found here: oxiceutics.com

Support the show

Books:

Super Gut: The 4-Week Plan to Reprogram Your Microbiome, Restore Health, and Lose Weight

Wheat Belly: Lose the Wheat, Lose the Weight and Find Your Path Back to Health; revised & expanded ed

I’ve spent some time reflecting back on all my years practicing in hospitals, often not sleeping for extended periods, sometimes days, covering hospitals floors and ICUs, resuscitating people who experienced cardiac arrests, taking them to the cath lab to open arteries, but also witnessing people with all sorts of other health conditions: cancers, wound infections, sepsis, delirium, the various stages of dementia, and hundreds of other debilitating disease.

I now recognize that, looking back, so many health conditions can be better understood in light of the contribution of the microbiome, i.e., the trillions of microbes occupying the gastrointestinal tract from mouth to anus, the nasal sinuses, the airways, the brain, the prostate, the vagina and uterus, the skin—virtually every part of the human body. We all know about acute bacterial infections. But I’m talking about something different. While microbes exert effects via a number of different routes—think the gut-brain axis, the gut-skin axis, the gut-muscle axis, effects exerted via hormones, inflammatory mediating proteins, and bacterial breakdown products. But beyond this, there is a curious phenomenon in which bacteria and fungi themselves, by a number of means, travel through the body to take up residence and cause trouble. But the “trouble” is not an infection in the conventional sense, but something different, less acute, less urgent, less dramatic, but nonetheless playing a big role in your health. This is the fascinating and scary phenomenon called “translocation,” the topic for this episode of the Defiant Health podcast.

_______________________________________________________________________________

For BiotiQuest probiotics including Sugar Shift, go here.

A 15% discount is available for Defiant Health podcast listeners by entering discount code UNDOC15 (case-sensitive) at checkout.*
_________________________________________________________________________________

Get your 15% Paleovalley discount on fermented grass-fed beef sticks, Bone Broth Collagen, low-carb snack bars and other high-quality organic foods here.*

For 12% off every order of grass-fed and pasture-raised meats from Wild Pastures, go here.
_____________________________________________________________________________

MyReuteri and Gut to Glow can be found here: oxiceutics.com

Support the show

Books:

Super Gut: The 4-Week Plan to Reprogram Your Microbiome, Restore Health, and Lose Weight

Wheat Belly: Lose the Wheat, Lose the Weight and Find Your Path Back to Health; revised & expanded ed