Dr Andrew M. Kiselica, narrating a new blog he wrote for the Dementia Researcher website.

Why are preclinical Alzheimer’s trials struggling to show results? Andrew and colleagues argue the issue may not just be biology or timing, but how we define “normal.” By grouping cognitively unimpaired individuals together, trials overlook meaningful differences in subtle symptoms. This blog explores how recognising objective subtle cognitive decline, supported by digital tools and refined measures, could improve participant selection and increase the chances of detecting real treatment effects.

Find the original text, and narration here on our website.

https://www.dementiaresearcher.nihr.ac.uk/blog-why-normal-cognition-is-hindering-preclinical-alzheimers-trials/

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Dr Andrew M. Kiselica is an Associate Professor at the University of Georgia whose work focuses on early detection of cognitive decline in Alzheimer’s disease. He contributes to the Working Group on Objective Subtle Cognitive Decline in Alzheimer’s Disease.

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Rahul Sidhu, narrating a new blog he wrote for the Dementia Researcher website.

In this blog, Rahul shares his experience at the Alzheimer’s Research UK conference, highlighting the breadth of dementia research and the sense of progress across the field. From clinical trials and molecular biology to AI, nutrition and the gut brain axis, the blog captures how diverse approaches are shaping our understanding of dementia. Alongside scientific advances, Rahul reflects on the importance of collaboration, early career researcher engagement, and the growing momentum driving the field forward.

Find the original text, and narration here on our website.

​Rahul Sidhu is a PhD student at The University of Sheffield, focusing on the effects of heart disease on dementia in preclinical models of Alzheimer's disease. His research aims to uncover how cardiovascular health influences neurodegenerative conditions, potentially leading to novel therapeutic strategies.​ Find Rahul on LinkedIn

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Jacqui Kerr narrates her blog written for Dementia Researcher.

Site Initiation Visits mark the transition from clinical trial / study setup to delivery, ensuring research sites are fully prepared before recruitment begins. In this blog, Jacqui explains how SIVs bring together protocol training, regulatory checks, role delegation, and data processes to create a clear, shared understanding across the research team. Far from a routine step, the SIV lays the groundwork for safe, compliant, and consistent trial delivery, helping protect participants and support reliable results.

Find the original text, and narration here on our website.

https://www.dementiaresearcher.nihr.ac.uk/blog-how-site-initiation-visits-work-and-why-they-matter/

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