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If you live in an area with more high-heat days, with a heat index above 90°F, you are likely to experience faster biological aging than if you reside in a cooler region. In fact, you are likely to age an extra 14 months over a six-year period.

This study from the University of Southern California just published in Science measured epigenetic changes in 3,686 subjects 56 years old and older. DNA methylation patterns were used to estimate biological aging. The data suggests that extreme heat may speed up aging in older adults at the molecular level.

Older adults are vulnerable to heat-driven body damage because ineffective sweating makes it harder for their bodies to cool down. This latest information suggests that traditional warm weather retirement destinations that now clock many days of extreme heat may be unhealthy.

https://www.science.org/doi/10.1126/sciadv.adr0616

#heat #aging

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So say neurologists at Harvard’s Brigham and Women’s Hospital. In a mouse model, they show that a nasal spray containing an anti-CD3 monoclonal antibody significantly reduces brain inflammation and speeds recovery after a traumatic brain injury (TBI).

This antibody, sprayed into the nasal cavities, activates regulatory T cells, Tregs, that then travel to the brain and release IL-10 that in turn reduces microglial-medial inflammation there.

This anti-CD3 nasal spray must still prove its effectiveness in humans. If so, it will become a treatment for the TBI that follows concussions, motor vehicle accidents, and other sports-related head trauma.

https://www.nature.com/articles/s41593-025-01877-7

#traumaticbraininjury #tbi #sports #cd3 #treg #il10 #mva #nasalspray

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University of South Carolina neurologists just reported to the International Stroke Conference that that regular flossing lowers the risk of certain strokes. Their study followed 6,278 participants for more than 25 years.

Those who flossed at least once weekly had a 21% lower incidence of ischemic stroke and a 44% lower risk of stroke associated with atrial fibrillation. The flossing prevents gum disease and reduces plaque buildup that both increase the level of inflammation in brain blood vessels but also in the heart leading to atrial fibrillation.

There is growing evidence that oral health is closely linked to heart health. Regular flossing as well as brushing are habits that have major health benefits. The study looked at once a week, but we all should be flossing as well as brushing after every meal.

https://www.medscape.com/viewarticle/regular-flossing-tied-reduced-ischemic-stroke-risk-2025a10002t7?ecd=a2a

#flossing #stroke #periodontitis #plaque #inflammation #atrialfibrillation