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If you are taking a proton pump, inhibitor such as omeprazole, Prilosec, esomeprazole, Nexium, or lansoprazole, Prevacid, you are likely not taking it at an optimal time with respect to meals. Most directions given with these drugs vaguely recommend taking them an hour or so before eating. Lab data pinpoints a more specific time.

It turns out that the best time to take any of these drugs is exactly 20 to 30 minutes before you begin eating. Let’s find out why.

The role of these proton pump inhibitors is to shut off acid production in the stomach. They work on acid producing cells in the stomach lining known as parietal cells. However, the drugs as you swallow them are not capable of performing this task. They must first be converted to active forms within the acidic crevices of the parietal cells called canaliculi. This process requires approximately 20 to 30 minutes to occur.

If you begin eating before taking these drugs or before 20-30 minutes after taking them, their acid suppressing effect will be reduced. If you wait too long after taking the drugs before eating, the optimal acid reduction by the active form of the drug will have occurred and the food you are eating will trigger far more stomach acid than is desirable.

So, to repeat, take any of these proton pump inhibitors exactly 20 to 30 minutes before eating a meal, whether that be breakfast or, if you’re taking the drug twice a day, dinner.

Effect of Food and Dosing Regimen on Safety and Efficacy of Proton Pump Inhibitors Therapy—A Literature Review - https://pmc.ncbi.nlm.nih.gov/articles/PMC8036504/

#protonpumpinhibitors # ppi #acid #prilosec #nexium #prevacid

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A painless, shot-free urine test could diagnose prostate cancer at its earliest, treatable stages. Biochemists in Sweden, the UK, and China, led by those at the Karolinska Institute, studied mRNA activity in more than 2000 patients with and without prostate cancers. They used AI to identify the proteins specific for prostate cancer that show up in the urine of those with this disease.

Following this identification phase, the researchers now plan to further validate this urine prostatic cancer test in larger clinical trials. Once this type of testing becomes the standard for prostatic cancer diagnosis, expect its use for monitoring following the medical and surgical therapeutic measures to eradicate prostate cancer.

https://dx.doi.org/10.1158/0008-5472.CAN-25-0269

https://medicalxpress.com/news/2025-04-urine-reveal-prostate-cancer.html

#prostate #cancer #urine #screening #ai

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A high tech bandage combining the power of biosensors, microfluidics, and machine learning capably detects signs of wound infection and inflammation some 3 days before clinical signs appear. Developed by bioengineers at Caltech, the California Institute of Technology, and surgeons at the USC School of Medicine, the iCares device not only continuously monitors the wound fluids for reactive oxygen, nitrogen species, pH, and temperature, but it removes and facilitates healing by keeping the tissues dry. It transmits data to a smartphone app using Bluetooth.

Following preclinical studies in diabetic mice, the research team tested the smart bandage in 20 patients with chronic wounds due to diabetes and suboptimal blood flow. Their smartphone algorithm is able to classify wound severity and healing potential. Their study now appears in the journal Science Translational Medicine.

https://www.science.org/doi/10.1126/scitranslmed.adt0882

https://www.sciencedaily.com/releases/2025/04/250423163909.htm

#wound #healing #smartbandage #icares #wearables #diabetes