Are you using liquid biopsies in your practice? Join Drs Benjamin Schlechter and Pashtoon Kasi as they review the latest clinical applications of ctDNA and liquid biopsies in colorectal cancer.

Relevant disclosures can be found with the episode show notes on Medscape https://www.medscape.com/viewarticle/1000089. The topics and discussions are planned, produced, and reviewed independently of advertisers. This podcast is intended only for US healthcare professionals.

Resources

Colon Cancer https://emedicine.medscape.com/article/277496-overview

Using Circulating Tumor DNA in Colorectal Cancer: Current and Evolving Practices https://pubmed.ncbi.nlm.nih.gov/35839443/

Methylomics and Cancer: The Current State of Methylation Profiling and Marker Development for Clinical Care https://pubmed.ncbi.nlm.nih.gov/37840147/

Circulating Tumor DNA (ctDNA) for Informing Adjuvant Chemotherapy (ACT) in Stage II/III Colorectal Cancer (CRC): Interim Analysis of BESPOKE CRC Study https://ascopubs.org/doi/10.1200/JCO.2024.42.3_suppl.9

Molecular Residual Disease and Efficacy of Adjuvant Chemotherapy in Patients With Colorectal Cancer https://pubmed.ncbi.nlm.nih.gov/36646802/

CIRCULATE-Japan: Circulating Tumor DNA-Guided Adaptive Platform Trials to Refine Adjuvant Therapy for Colorectal Cancer https://pubmed.ncbi.nlm.nih.gov/33931919/

Minimal Residual Disease-Directed Adjuvant Therapy for Patients With Early-Stage Colon Cancer: CIRCULATE-US https://pubmed.ncbi.nlm.nih.gov/36260786/

Circulating Tumor DNA Analysis Guiding Adjuvant Therapy in Stage II Colon Cancer https://pubmed.ncbi.nlm.nih.gov/35657320/

Circulating Tumor DNA as a Predictive Biomarker in Adjuvant Chemotherapy for Patients With Stage 2a Colon Cancer (COBRA) https://pubmed.ncbi.nlm.nih.gov/33999346/

Clonal Hematopoiesis Detection in Patients With Cancer Using Cell-Free DNA Sequencing https://pubmed.ncbi.nlm.nih.gov/36989374/

Commercial ctDNA Assays for Minimal Residual Disease Detection of Solid Tumors https://pubmed.ncbi.nlm.nih.gov/34725800/

The PEGASUS Trial: Post-Surgical Liquid Biopsy-Guided Treatment of Stage III and High-Risk Stage II Colon Cancer Patients https://www.annalsofoncology.org/article/S0923-7534(23)04164-9/fulltext

Microsatellite Instability: A Review of What the Oncologist Should Know https://pubmed.ncbi.nlm.nih.gov/31956294/

Utility and Debate of Liquid Biopsy Assays in Surveillance Setting https://dailynews.ascopubs.org/do/utility-and-debate-liquid-biopsy-assays-surveillance-setting

Radioembolization With Chemotherapy for Colorectal Liver Metastases: A Randomized, Open-Label, International, Multicenter, Phase III Trial https://pubmed.ncbi.nlm.nih.gov/34541864/