Drs Michael J. Mauro and Jerald P. Radich discuss monitoring and diagnostics in chronic myeloid leukemia, including the Philadelphia chromosome and how it plays into the current treatment of CML.

Relevant disclosures can be found with the episode show notes on Medscape (https://www.medscape.com/viewarticle/989028). The topics and discussions are planned, produced, and reviewed independently of advertisers. This podcast is intended only for US healthcare professionals.

Resources

Chronic Myelogenous Leukemia (CML) https://emedicine.medscape.com/article/199425-overview

Genetics, Philadelphia Chromosome https://www.ncbi.nlm.nih.gov/books/NBK560689/

Reverse Transcriptase-Polymerase Chain Reaction https://emedicine.medscape.com/article/2093395-overview

Why Is It Critical to Achieve a Deep Molecular Response in Chronic Myeloid Leukemia? https://pubmed.ncbi.nlm.nih.gov/33054104/

Precision Oncology: Who, How, What, When, and When Not? https://ascopubs.org/doi/full/10.1200/EDBK_174176

Discovery of the Philadelphia Chromosome: A Personal Perspective https://pubmed.ncbi.nlm.nih.gov/17671636/

Dr. Janet Davison Rowley https://cfmedicine.nlm.nih.gov/physicians/biography_282.html

Metaphase https://www.genome.gov/genetics-glossary/Metaphase

A Primer on Genetic Testing https://www.medscape.com/viewarticle/505220_7

WHO 2016 Definition of Chronic Myeloid Leukemia and Tyrosine Kinase Inhibitors https://pubmed.ncbi.nlm.nih.gov/31612694/

Flow Cytometry: An Overview https://pubmed.ncbi.nlm.nih.gov/29512141/

Accelerated Phase Chronic Myelogenous Leukemia https://www.cancer.gov/publications/dictionaries/cancer-terms/def/accelerated-phase-chronic-myelogenous-leukemia

Treatment-Free Remission in CML: Who, How, and Why? https://pubmed.ncbi.nlm.nih.gov/29222243/

Digital PCR for BCR-ABL1 Quantification in CML: Current Applications in Clinical Practice https://pubmed.ncbi.nlm.nih.gov/33283168/

Tyrosine Kinase Inhibitors https://www.ncbi.nlm.nih.gov/books/NBK563322/

t(14;18) Translocations and Risk of Follicular Lymphoma https://pubmed.ncbi.nlm.nih.gov/18648003/

CHIP https://www.cancer.gov/publications/dictionaries/genetics-dictionary/def/chip

The Max Foundation https://themaxfoundation.org/

BCR-ABL Fusion Gene https://www.cancer.gov/publications/dictionaries/cancer-terms/def/bcr-abl-fusion-gene