What if we could target cancer at its metabolic core? In this episode of The Metabolic Link, Dr. Dominic D’Agostino is joined by Dr. Tomás Duraj, a physician and cancer metabolism researcher working alongside Dr. Thomas Seyfried.

Dr. Duraj is the lead author of a groundbreaking review on ketogenic metabolic therapy for glioblastoma, bringing together leading experts to explore how metabolic strategies could reshape cancer treatment.

In this deep-dive conversation, they discuss the bioenergetics of cancer, the role of mitochondria, the Warburg effect, and why targeting glucose and glutamine metabolism may be the key to making standard cancer therapies more effective.

Whether you’re a researcher, clinician, or someone interested in the latest advancements in cancer therapy, this episode is packed with insights that could redefine the way we think about cancer treatment. Watch the full episode here or listen on your favorite podcast player for this must-hear discussion on the future of metabolic therapy for cancer!

Read Dr. Duraj's paper: Clinical research framework proposal for ketogenic metabolic therapy in glioblastoma

About Dr. Tomás Duraj
Dr. Tomás Duraj is a Czech physician-scientist, receiving his Medical Degree from the Rey Juan Carlos University and his PhD in Translational Medicine from the CEU San Pablo University (Madrid, Spain). His research focuses on studying the potential of bioenergetic modulation in cancer metabolism, with special emphasis on glioblastoma, the most aggressive and lethal primary brain tumor. After developing cancer research at the team of Dr. Ayuso Sacido, he joined Dr. Thomas N. Seyfried’s laboratory in Boston College. His goal is to advance our understanding of metabolic oncology on a rigorous, evidence-based background, making it part of the standard oncology toolkit.

Special thanks to the sponsors of this episode:

• Puori: Get 20% off Puori supplements at https://puori.com/METABOLICLINK and use the code METABOLICLINK
• Fatty15: Get an additional 15% off their 90-day subscription Starter Kit by going to https://fatty15.com/METABOLICLINK and use code METABOLICLINK.
• MUDWTR: Get up to 43% off with code METABOLICLINK at https://mudwtr.com/METABOLICLINK

In every episode of The Metabolic Link, we'll uncover the very latest research on metabolic health and therapy. If you like this episode, please share it, subscribe, follow, and leave us a comment or review on whichever platform you use to tune in!

You can find us on all your major podcast players here and full episodes are also up on our Metabolic Health Summit YouTube channel!

Find us on social:

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Please keep in mind: The Metabolic Link does not provide medical or health advice, but rather general information that does not serve as a substitute for a licensed healthcare professional. Never delay in seeking medical advice from an appropriately licensed medical provider for any health condition that you may have.

Become a member of The Metabolic Initiative to access exclusive ad-free episodes, 100s of videos on metabolic health, and earn CMEs: https://membership.metabolicinitiative.com

Can a ketogenic diet revolutionize the management of type 1 diabetes? In this episode of The Metabolic Link, Dr. Ian Lake, a UK-based physician and type 1 diabetes advocate, shares his personal and professional journey in using low-carb and ketogenic diets to improve metabolic control.

Diagnosed with type 1 diabetes at 36, Dr. Lake initially followed conventional high-carb recommendations—until he discovered the power of nutritional ketosis. He breaks down how reducing insulin volumes, optimizing glucose levels, and becoming fat-adapted transformed his health and life.

From running 700 miles while following a ketogenic diet to leading type 1 diabetes retreats, Dr. Lake shares actionable insights on metabolic flexibility, insulin sensitivity, and the real-world implications of a ketogenic approach.

Special thanks to the sponsors of this episode:

• Puori: Get 20% off Puori supplements! If you choose their already discounted subscription, that's almost a third off the price! Visit https://puori.com/METABOLICLINK and use the code METABOLICLINK
• Maui Nui Venison: Gain access to a limited collection of Dom’s favorite Maui Nui products at https://mauinuivenison.com/METABOLICLINK
• Zocdoc: Visit https://Zocdoc.com/METABOLICLINK to find and instantly book a top-rated doctor

In every episode of The Metabolic Link, we'll uncover the very latest research on metabolic health and therapy. If you like this episode, please share it, subscribe, follow, and leave us a comment or review on whichever platform you use to tune in!

You can find us on all your major podcast players here and full episodes are also up on our Metabolic Health Summit YouTube channel!

Find us on social:

• Instagram
• Facebook
• YouTube
• LinkedIn

Please keep in mind: The Metabolic Link does not provide medical or health advice, but rather general information that does not serve as a substitute for a licensed healthcare professional. Never delay in seeking medical advice from an appropriately licensed medical provider for any health condition that you may have.

Become a member of The Metabolic Initiative to access exclusive ad-free episodes, watch 100s of videos on metabolic health, and earn CMEs here.

In this powerful and unfiltered episode of The Metabolic Link, we're sharing a full presentation by Chad Vanags, a former SaaS executive and entrepreneur who has turned his stage 4 lung cancer diagnosis into a mission to reshape the way we think about healing. Recorded live at Metabolic Health Summit in January of 2024, Chad shares his journey of becoming metabolically, physically, and mentally elite in the fight against cancer.

Through his deeply personal story, Chad provides a rare and essential patient perspective, shedding light on the gaps in traditional cancer care—from nutrition and communication to the importance of mindset and metabolic health. His insights challenge clinicians, researchers, and patients alike to rethink the medical status quo, spark innovation, and inspire transformative conversations.

This episode is more than just a story of resilience—it’s a call to action to integrate patient voices into the heart of healthcare and foster a collaborative approach to healing.

Listen to this episode or watch on YouTube to explore Chad’s journey, the lessons he’s learned, and his hope for the future of patient-centered care.

Special thanks to the sponsors of this episode:

• Fatty15: Get 15% off their 90-day subscription Starter Kit with the code METABOLICLINK at fatty15.com/METABOLICLINK
• MUD/WTR: Start your new morning ritual & get up to 43% off your MUDWTR with code METABOLICLINK at mudwtr.com/METABOLICLINK

In every episode of The Metabolic Link, we'll uncover the very latest research on metabolic health and therapy. If you like this episode, please share it, subscribe, follow, and leave us a comment or review on whichever platform you use to tune in!

You can find us on all your major podcast players here and full episodes are also up on our Metabolic Health Summit YouTube channel!

Find us on social:

• Instagram
• Facebook
• YouTube
• LinkedIn

Please keep in mind: The Metabolic Link does not provide medical or health advice, but rather general information that does not serve as a substitute for a licensed healthcare professional. Never delay in seeking medical advice from an appropriately licensed medical provider for any health condition that you may have.

Become a member of The Metabolic Initiative to access exclusive ad-free episodes and earn CMEs here.

In this journal club episode, host Victoria Field is joined by Dr. Angela Poff and Dr. Dominic D’Agostino to dive into two groundbreaking studies shaping our understanding of metabolism and its role in health and disease. The team explores the nuances of a recent randomized controlled trial on ketogenic diets, free sugar restriction, and their effects on glucose tolerance, lipid metabolism, and the gut microbiome. Then, they tackle a cutting-edge study uncovering the molecular mechanisms of ketogenic diets in reshaping cancer metabolism through lysine beta-hydroxybutylaration.

From the clinical implications of these findings to the potential of ketone supplementation, this episode is packed with insights for researchers, clinicians, and health enthusiasts. Don’t miss the opportunity to learn how these discoveries could shape the future of precision medicine.

🔍 Study 1: Ketogenic diet but not free-sugar restriction alters glucose tolerance, lipid metabolism, peripheral tissue phenotype, and gut microbiome: RCT

🔍 Study 2: Ketogenic diet reshapes cancer metabolism through lysine β-hydroxybutyrylation

Referenced study related to cardiometabolic health - Carbohydrate Restriction-Induced Elevations in LDL-Cholesterol and Atherosclerosis: The KETO Trial

Special thanks to the sponsors of this episode:
Genova Connect: Receive 15% off any of their tests with code metaboliclink here
Fatty15: Get 15% off their 90-day subscription Starter Kit with the code METABOLICLINK here
Maui Nui: Get 15% off your first order of Maui Nui with the code METABOLICLINK by visiting this link

In every episode of The Metabolic Link, we'll uncover the very latest research on metabolic health and therapy. If you like this episode, please share it, subscribe, follow, and leave us a comment or review on whichever platform you use to tune in!

You can find us on all your major podcast players here and full episodes are also up on our Metabolic Health Summit YouTube channel!

Find us on social:

• Instagram
• Facebook
• YouTube
• LinkedIn

Please keep in mind: The Metabolic Link does not provide medical or health advice, but rather general information that does not serve as a substitute for a licensed healthcare professional. Never delay in seeking medical advice from an appropriately licensed medical provider for any health condition that you may have.

Join our free Live Q&A with Lauren on December 18th and become a member of The Metabolic Initiative to access exclusive ad-free episodes and earn CMEs. Register here!

In this episode of The Metabolic Link, host Victoria Field sits down with Lauren Kennedy West, a passionate mental health advocate and social worker who was diagnosed with schizoaffective disorder in 2016. Lauren reveals her extraordinary journey of using metabolic therapy to not only manage but reverse debilitating symptoms, transforming her life in ways she once thought impossible.

This deeply compelling conversation delves into Lauren’s personal story, the stigma surrounding mental health, and the challenges of balancing medications with metabolic therapy. Lauren also shares her mission to bring metabolic therapy to the forefront of mental health treatment, redefining possibilities in the field of metabolic psychiatry.

Lauren’s bravery and advocacy are sparking new conversations about recovery and shining a light on the untapped potential of metabolic approaches to mental health. Don’t miss this inspiring episode—and be sure to join Lauren for a Live Q&A on December 18th through The Metabolic Initiative platform. Learn more here!

Special thanks to the sponsor of this episode:

Genova Connect: Gain access to advanced lab tests in the comfort of your own home. Receive 15% off any test with code metaboliclink by clicking here.

AG1: New subscribers get a FREE $76 gift when you sign up. You’ll get a Welcome Kit, a bottle of D3K2 AND 5 free travel packs in your first box. Visit this link.

Ned: Get 15% off Ned products with code METABOLICLINK by visiting this link.

In every episode of The Metabolic Link, we'll uncover the very latest research on metabolic health and therapy. If you like this episode, please share it, subscribe, follow, and leave us a comment or review on whichever platform you use to tune in!

You can find us on all your major podcast players here and full episodes are also up on our Metabolic Health Summit YouTube channel!

Find us on social:

• Instagram
• Facebook
• YouTube
• LinkedIn

Please keep in mind: The Metabolic Link does not provide medical or health advice, but rather general information that does not serve as a substitute for a licensed healthcare professional. Never delay in seeking medical advice from an appropriately licensed medical provider for any health condition that you may have.

Become a member of The Metabolic Initiative to access exclusive ad-free episodes and earn CMEs: https://membership.metabolicinitiative.com

In this special episode of The Metabolic Link, we’re sharing an exclusive panel discussion from Metabolic Health Summit 2024, where leading experts dive into the science and real-world applications of allulose, a natural low-calorie sweetener with potential metabolic health benefits.

Featuring insights from Dr. Richard Johnson, Dr. Jeff Volek, Dr. Ben Bikman, Dr. Andrew Koutnik, and Dr. Dominic D’Agostino, this conversation explores how allulose influences glucose levels, insulin sensitivity, weight management, and GLP-1 stimulation for satiety and glucose control. The panel also addresses questions about safety, its role as a sugar substitute, and its potential impact on broader metabolic pathways.

Whether you're new to allulose or looking to deepen your understanding of metabolic health, this episode offers valuable perspectives from some of the field’s top researchers.

Special thanks to the sponsor of this episode:

• Genova Connect, powered by Genova Diagnostics offers easy access to advanced lab tests. Receive 15% off any of their tests with code metaboliclink at https://gdx.net/themetaboliclink
• AG1: New subscribers get a FREE $76 gift when you sign up. You’ll get a Welcome Kit, a bottle of D3K2 AND 5 free travel packs in your first box. Visit: https://DrinkAG1.com/METABOLICLINK
• Ned: Get 15% off Ned products with code METABOLICLINK at https://helloned.com/metaboliclink

In every episode of The Metabolic Link, we'll uncover the very latest research on metabolic health and therapy. If you like this episode, please share it, subscribe, follow, and leave us a comment or review on whichever platform you use to tune in!

You can find us on all your major podcast players here and full episodes are also up on our Metabolic Health Summit YouTube channel!

Find us on social:

• Instagram
• Facebook
• YouTube
• LinkedIn

Please keep in mind: The Metabolic Link does not provide medical or health advice, but rather general information that does not serve as a substitute for a licensed healthcare professional. Never delay in seeking medical advice from an appropriately licensed medical provider for any health condition that you may have.

Become a member of The Metabolic Initiative to access exclusive ad-free episodes and earn CMEs. Your first 7 days are free! PLUS use code blackfriday at checkout to receive 50% off your first 3 months (through November 29th): https://membership.metabolicinitiative.com

In this episode of The Metabolic Link filmed at Metabolic Health Summit 2024, Dr. Valter Longo shares his latest research on the fasting mimicking diet (FMD) and its powerful impact on aging, metabolic diseases, and cancer treatment. With a focus on periodic fasting interventions, Dr. Longo highlights the role of FMD in activating stem cells, enhancing cellular repair mechanisms, and even reversing metabolic dysfunctions like insulin resistance and type 1 diabetes.

Dr. Longo’s work is paving the way for more accessible, non-invasive therapies for chronic conditions, with far-reaching implications for aging, cancer prevention, and metabolic health. If you’re an academic, medical professional, or researcher, you won’t want to miss this in-depth discussion on how FMD could shape the future of medicine.

Valter Longo, PhD, is the Edna Jones Professor in Gerontology, the Director of the USC Longevity Institute and group leader at the IFOM cancer research institute in Milan, Italy. His laboratories study the fundamental mechanisms of aging in yeast, rodents and humans by using genetics and biochemistry techniques. The focus is on the nutrient-response signal transduction pathways that regulate disease and longevity. This work led to the discovery of the effects of periodic fasting and fasting mimicking diets on multi-system stem cell activation and regeneration in mice, and to clinical trials on a range of age-related diseases.

Special thanks to the sponsors of this episode:
Genova Connect: Receive 15% off any of their tests with code metaboliclink at https://gdx.net/themetaboliclink
AG1: This November, AG1 is offering a free gift with your first subscription plus a Welcome Kit at https://DrinkAG1.com/METABOLICLINK—while supplies last!
Ned: Get 15% off Ned products with code METABOLICLINK at https://helloned.com/metaboliclink

Learn more about Dr. Valter Longo here.

In every episode of The Metabolic Link, we'll uncover the very latest research on metabolic health and therapy. If you like this episode, please share it, subscribe, follow, and leave us a comment or review on whichever platform you use to tune in!

You can find us on all your major podcast players here and full episodes are also up on our Metabolic Health Summit YouTube channel!

Find us on social:

• Instagram
• Facebook
• YouTube
• LinkedIn

Please keep in mind: The Metabolic Link does not provide medical or health advice, but rather general information that does not serve as a substitute for a licensed healthcare professional. Never delay in seeking medical advice from an appropriately licensed medical provider for any health condition that you may have.

Become a member of The Metabolic Initiative to access exclusive ad-free episodes and earn CMEs. Your first 7 days are free! PLUS use code blackfriday at checkout to receive 50% off your first 3 months (through November 29th): https://membership.metabolicinitiative.com

In this episode of the Metabolic Link podcast, we are joined by Beth Zupec-Kania, an experienced dietitian and nutritionist with over 30 years in the field of ketogenic metabolic therapy. Beth has played a pivotal role in the development and implementation of ketogenic diets for the treatment of epilepsy, and her work has expanded to include a variety of neurological and psychiatric conditions, including anorexia nervosa, bipolar disorder, and schizophrenia.

Beth’s expertise is shaped by years of practical experience and her involvement with The Charlie Foundation, where she helped pioneer the use of ketogenic metabolic therapy in clinical settings. In this episode, we explore how this therapy has evolved from a treatment for refractory epilepsy to a promising option for mental health conditions and other complex disorders.

We discuss the latest evidence supporting ketogenic therapy, its application in clinical practice, and the challenges healthcare providers face in integrating these therapies into standard care. Beth also shares her insights into the future of metabolic therapies in healthcare, highlighting the growing need for education and clinical expertise in this transformative area.

If you’re a medical professional interested in understanding how ketogenic metabolic therapies can improve patient outcomes across a range of conditions, this episode is a must-listen.

Special thanks to the sponsors of this episode:
Genova Connect: Receive 15% off any of their tests with code metaboliclink at https://gdx.net/themetaboliclink
Ned: Get 15% off Ned products with code METABOLICLINK at helloned.com/metaboliclink

Learn more about Beth Zupec-Kania here: https://www.bethzupeckania.com

In every episode of The Metabolic Link, we'll uncover the very latest research on metabolic health and therapy. If you like this episode, please share it, subscribe, follow, and leave us a comment or review on whichever platform you use to tune in!

You can find us on all your major podcast players here and full episodes are also up on our Metabolic Health Summit YouTube channel!

Find us on social:

• Instagram
• Facebook
• YouTube
• LinkedIn

Please keep in mind: The Metabolic Link does not provide medical or health advice, but rather general information that does not serve as a substitute for a licensed healthcare professional. Never delay in seeking medical advice from an appropriately licensed medical provider for any health condition that you may have.