The Synthesis of Wellness

Auteur(s): Chloe Porter
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  • Résumé

  • Your host and biohacker, Chloe Porter, has a background in engineering, innovation, and research. Her analytical background coupled with her journey in overcoming a brain tumor and defeating several chronic illnesses enables her to approach health and wellness in an innovative way, and now more than ever, she is ready to share her biohacking secrets and expose cutting-edge research. Support this podcast: https://podcasters.spotify.com/pod/show/chloe-porter6/support
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Épisodes
  • 149. The Gut Microbiome & Serotonin Synthesis | Impacts of Intestinal Dysbiosis on Serotonin Production, Impacts of Low Serotonin on Gut Motility, & More

    149. The Gut Microbiome & Serotonin Synthesis | Impacts of Intestinal Dysbiosis on Serotonin Production, Impacts of Low Serotonin on Gut Motility, & More
    Nov 1 2024
    In this episode, we explore serotonin synthesis within enterochromaffin (EC) cells in the gut, detailing how tryptophan is converted into serotonin through enzymatic processes. We examine the role of gut microbiota-derived metabolites, such as short-chain fatty acids (SCFAs), in modulating the synthesis of serotonin including impacting tryptophan hydroxylase activity. We explore serotonin's interactions with receptors on enteric neurons and vagal afferent fibers, analyzing how these signaling pathways influence gut motility. Finally, we uncover conditions and symptoms associated with low serotonin production and the importance of the intestinal microbiome. Topics: 1. Introduction to Gut-Produced Serotonin - Serotonin production within the gut. - Serotonin’s role beyond mood. - Synthesis, causes of low serotonin, related GI symptoms. 2. Gut Lining Structure and Cell Types - Layers of the gut lining, focusing on the mucosa. - Description of epithelial cells, including enterocytes, goblet cells, Paneth cells, and enteroendocrine cells. - Role of enterochromaffin (EC) cells in serotonin production. 3. Serotonin Synthesis in EC Cells - Location and function of EC cells. - How EC cells synthesize serotonin from tryptophan. 4. Biochemical Pathway of Serotonin Production - Step-by-step process: conversion of tryptophan to serotonin. - Enzymes involved, including TPH1 and AADC. - Importance of tryptophan availability in serotonin synthesis. 5. Storage and Release of Serotonin in EC Cells - Role of VMAT1 in serotonin storage within vesicles. - Controlled release. 6. Triggers for Serotonin Release - Physical triggers: mechanical stretch, pressure from food intake. - Chemical triggers: microbial metabolites, bile acids. - Receptors involved (GPCRs, TGR5) and signaling pathways. 7. Release of Serotonin into Intestinal Lining Layers - Serotonin exocytosis and interaction with nearby cells. - Release of serotonin on both luminal and basolateral sides of EC cells. - How luminal and basolateral release affects gut motility and barrier function. 8. Serotonin’s Role in Gut Motility - Interaction with 5-HT3 and 5-HT4 receptors on enterocytes and enteric neurons. - Activation of the enteric nervous system (ENS) in the submucosal and myenteric plexuses. - Coordination with pacemaker cells for peristaltic movement. 9. Immune Function and Serotonin in the Gut - Effect on immune cells. 10. Gut-Brain Communication via Serotonin and the Vagus Nerve - Activation of vagal afferent fibers by serotonin. 11. Contributing Factors to Low Serotonin Production - Impact of dysbiosis and reduced SCFA production. - SIBO specifically. - Intestinal inflammation in general. - Imbalanced microbiota and inflammation can disrupt EC cell function. 12. Manifestations of Low Serotonin in the Gut - Effects on motility: constipation, dysmotility... - Common GI symptoms, including bloating, discomfort, and fullness. - Association with conditions like IBS. 13. Supporting Serotonin Production in the Gut - Painting a full picture and identifying root causes. - Strategies to foster a healthy gut microbiome. - Role of sunlight and tryptophan-rich foods in serotonin production. - Stool testing for microbiome imbalances. Thanks for tuning in! "⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠75 Gut-Healing Strategies & Biohacks⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠" Follow Chloe on Instagram ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠@synthesisofwellness⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ Follow Chloe on TikTok @chloe_c_porter Visit ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠synthesisofwellness.com⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ --- Support this podcast: https://podcasters.spotify.com/pod/show/chloe-porter6/support
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    18 min
  • 148. 1,25-Dihydroxycholecalciferol & The Brain | Forms of Vitamin D, Activation to 1,25-Dihydroxycholecalciferol, Mechanisms of Action / Neuroprotective Effects of Vitamin D, Cognitive Symptoms

    148. 1,25-Dihydroxycholecalciferol & The Brain | Forms of Vitamin D, Activation to 1,25-Dihydroxycholecalciferol, Mechanisms of Action / Neuroprotective Effects of Vitamin D, Cognitive Symptoms
    Oct 25 2024
    In this episode, we explore the role of Vitamin D in brain health, focusing on how its active form, calcitriol (1,25-dihydroxyvitamin D3), influences cognitive function and neuroprotection. We’ll discuss the synthesis of Vitamin D, its conversion into its active form, and its ability to cross the blood-brain barrier to exert effects on neurons and glial cells. Additionally, we will highlight how calcitriol regulates gene expression through Vitamin D Response Elements (VDREs), impacting inflammation, antioxidant defense, and neurotrophic support. Finally, we touch on the symptoms of low Vitamin D and the link to cognitive decline. Topics: 1. Introduction to Vitamin D and the Brain - Forms of Vitamin D, synthesis, conversion/activation, and its role in the brain 2. Vitamin D - Vitamin D2 (ergocalciferol), plant-based sources like mushrooms - Vitamin D3 (cholecalciferol), UVB radiation, animal-based foods - Inactive forms 3. Synthesis and Conversion of Vitamin D3 - Synthesis in the skin: 7-dehydrocholesterol converts to pre-vitamin D3 - Conversion in the liver: 25-hydroxylase converts D3 to 25-hydroxyvitamin D (calcidiol) - Final activation in the kidneys: 1-alpha-hydroxylase converts calcidiol to 1,25-dihydroxycholecalciferol (calcitriol), the active form 4. Calcitriol and the Blood-Brain Barrier - Calcitriol’s lipophilic nature, crossing the BBB - The structure and function of the blood-brain barrier - How calcitriol diffuses across the BBB and reaches brain cells 5. Calcitriol's Role in the Brain - Interaction with Vitamin D receptors (VDRs) in neurons and glial cells - VDRs in key brain regions: hippocampus, prefrontal cortex, cerebellum, basal ganglia - Binding of calcitriol to VDRs, conformational change, and formation of the VDR-RXR complex 6. Gene Regulation via Vitamin D Response Elements (VDREs) - Overview of VDREs in promoter regions of genes - Role of calcitriol in activating or repressing gene transcription 7. Impact on Inflammatory Responses - VDREs in anti-inflammatory genes promote IL-10 expression - Calcitriol’s role in reducing pro-inflammatory cytokines like IL-6 and TNF-alpha 8. Neurotrophic Factors - VDREs’ role in regulating genes that promote BDNF - BDNF’s impact on neuron survival, growth, and synaptic connectivity 9. Antioxidant Enzymes - VDREs influence the expression of glutathione peroxidase and superoxide dismutase (SOD) - The role of these enzymes in defending neurons from oxidative stress 10. Brain Regions & Calcitriol - Hippocampus: Learning, memory, neurogenesis, synaptic plasticity - Prefrontal Cortex: Executive functions, mood regulation - Cerebellum: Motor control, cognitive processing, calcium homeostasis - Basal Ganglia: Movement regulation, protection of dopaminergic neurons - Amygdala: Emotion processing, fear, anxiety, stress response 11. Interconnection of Brain Regions - How Vitamin D’s effects on neurotransmitter regulation, anti-inflammatory action, and calcium homeostasis create a global protective effect. 12. Conclusion - Recap of calcitriol’s cellular mechanisms and neuroprotective effects - Symptoms of low Vitamin D Thank you to our episode sponsor: 1. Check out ⁠⁠⁠⁠⁠⁠⁠⁠⁠Daily Nouri⁠⁠⁠⁠⁠⁠⁠⁠⁠ and use code ⁠⁠⁠⁠⁠⁠⁠⁠⁠CHLOE20⁠⁠⁠⁠⁠⁠⁠⁠⁠ for 20% off your order. Thanks for tuning in! Get Chloe's Book Today! "⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠75 Gut-Healing Strategies & Biohacks⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠" Follow Chloe on Instagram ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠@synthesisofwellness⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ Follow Chloe on TikTok @chloe_c_porter Visit ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠synthesisofwellness.com⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ to purchase products, subscribe to our mailing list, and more! --- Support this podcast: https://podcasters.spotify.com/pod/show/chloe-porter6/support
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    19 min
  • 147. Mindfulness, Gratitude, Manifestation, Habit-Formation, & More with Ron & Carri, The Co-Founders of The Sparkle Revolution App

    147. Mindfulness, Gratitude, Manifestation, Habit-Formation, & More with Ron & Carri, The Co-Founders of The Sparkle Revolution App
    Oct 23 2024

    We are honored to be joined by Carri Norton and Ron Butterworth, the Co-Founders of the Sparkle Revolution App. Carri is an accomplished professional in software application development, with experience across various industries such as educational software, solar monitoring, energy management, and HVAC digital solutions. Starting her career as a software developer, she progressed into management and leadership roles, contributing to both startups and Fortune 500 companies. Her passion lies in creating user-centric software solutions that enhance customer experiences and make lives better. Ron’s professional career has been that of a hardware design engineer. He has had the opportunity to work on projects based in education, solar energy, agriculture, and augmented reality, to name a few. Together they were thrilled to combine their expertise with personal passions and launch Sparkle Revolution.


    Topics:

    1. Motivation to Create the App / Personal Journeys for Ron and Carri

    - Inspiration behind the app

    - Personal stories of Ron and Carri

    - Introduction to the app and its 4 "foundations"


    2. How the App’s Foundations Relate to Health

    - Overview of the 4 foundations

    - Impact of these foundations on mental, emotional, and physical health


    3. Science and Studies on Mindfulness and Gratitude

    - Research on mindfulness practices

    - Scientific evidence on the benefits of gratitude


    4. Examples of Mindfulness Exercises

    - Simple exercises for beginners

    - Techniques used to enhance daily mindfulness


    5. Manifestation and Visualization Techniques

    - How manifestation works on a psychological level

    - Rewiring the brain to embrace future opportunities


    6. Personal Examples of Manifestation in Action

    - Stories from Ron and Carri’s lives

    - Real-world outcomes from practicing manifestation


    7. Strategies for Integrating Mindfulness and Building Habits

    - Daily habits to foster mindfulness

    - Tips for sustainable habit formation


    8. Overview of the Sparkle Revolution App

    - How the app works

    - Features and functionality

    - Where to download the app


    9. Social Handles, Website, and Other Resources

    - Social media platforms

    - Official website and contact info

    - Additional tools or resources for further exploration


    To learn more and get the app, check out www.sparklerevolution.com

    Search for Sparkle Revolution on the Apple or Android stores.

    Visit them on social media @SparkleRevolutionApp

    Take advantage of an introductory offer! Use code CHLOE60 to get 60% off an annual subscription.


    Studies & Articles Mentioned:

    • Robert Emmons, Why Gratitude is Good
    • Article on National Library of Medicine about the benefits of mindfulness
    • https://sparklerevolution.com/mindfulness-and-happiness/




    --- Support this podcast: https://podcasters.spotify.com/pod/show/chloe-porter6/support
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    47 min

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