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athletic longevity and peak performance as we age© 2020-2025 wise athlete podcast Hygiène et mode de vie sain
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  • #179 | TRT: Less is More | Nayan Patel PharmD
    Mar 1 2026

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    Nayan Patel, PharmD
    • Doctor of Pharmacy (PharmD) degree from the University of Southern California School of Pharmacy and serves as adjunct faculty there.
    • Hormone health influences everything from energy and sleep to mood, metabolism, and libido—yet mainstream treatments are often driven by generic protocols and limited lab interpretations. Dr. Patel has helped thousands of patients find clarity and results by looking beyond “normal” hormone levels and building therapy around how people actually feel and function. He offers a practical view into what personalized hormone care should look like—and where most systems are getting it wrong.
    • He is globally regarded as an expert on glutathione, a molecule often referred to as the “master antioxidant,” and is recognized for research into its absorbable forms. He has authored a book titled The Glutathione Revolution: Fight Disease, Slow Aging & Increase Energy with the Master Antioxidant.
    • Find Dr Patel here: centraldrugsrx.com and here: aurowellness.com
    Discussion Points
    • The hard truth is that you cannot inject your way out of a broken lifestyle
    • Sex hormone optimization is a necessary but small piece of the puzzle.
    • Extra (more than the minimum) TRT is a poor solution to overcome poor lifestyle for stress and diet, and it comes with extra negative side effects.
    • Find the least effective dose for your physiology; use bio-identical hormones (have to use every 1-3 days)
    • How to “feel” like the young you. The solution pyramid is:
      • Sex hormones— 10% (necessary for older athletes but not sufficient)
      • Thyroid mgmt — 20% (pollution, autoimmune)
      • Diet / insulin - 30% (over eating, visceral fat)
      • Adrenals / Stress mgmt - 40% (lifestyle; sleep)
    • Also have to address oxidative stress issues (glutathione).
    Related Episodes & Links:
    • Episode 178 | Athletic Longevity isn't Easy | Brenden Egan PhD
    • Episode 155 | Hormonal Triple Whammy | Kyle Gillett MD
    • Episode 144 | Muscle for Athletic Performance | Mark Tarnopolsky MD PhD
    • Episode 115 | Winning Athletic Longevity | Rick Cohen MD & Daniel Tawfik, Healthspan
    • Episode 102 | Maximizing Performance Health | Jim Lavalle R.Ph.
    Help the show:

    3 ways to support our show:

    • Leave a review (or share this episode)
    • Check out our Fullscript site to save big on high quality supplements. Thank you!
    • Email us your questions at info@wiseathletes.com....
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    1 h et 8 min
  • #178 | Athletic Longevity isn't Easy | Brendan Egan, PhD
    Feb 15 2026

    Professional Supplements for Wise Athletes (click to see the "always on" discount)

    Brendan Egan, PhD
    • Associate Professor of Sport & Exercise Physiology at Dublin City University
    • Associate Dean for Research (Faculty of Science & Health)
    • Current research investigates skeletal muscle function and adaptation across the life course, with special interest in the synergy between nutrition and exercise interventions ranging from athletes to older adults.
    • Nutrients investigated include caffeine, creatine, omega-3 fatty acids, resveratrol, leucine, protein hydrolysates, beetroot juice, and exogenous ketones.
    • Outside of academia, through his sporting career as an Gaelic footballer, Brendan has had a lifelong association with sport, training and performance at all levels of competition from grassroots to elite level, and also practices in the field as a performance nutritionist with emphasis on intermittent field-based team sports, and endurance athletes, most recently with the Dublin Hurlers and the Irish Paratriathlon team.
    • Find Brendan's work here: https://www.researchgate.net/profile/Brendan-Egan and contact info here: https://www.dcu.ie/researchsupport/research-profile?person_id=35443
    • https://sigmanutrition.com/episode591/
    Discussion Points
    • Personal Peak & Glide Path— peak as high and as late as possible, then hang on baby.
    • “Use it or lose it”. It’s an old thing but now we lose faster and it’s harder to get back. Consistency is the name of the game now. Spikes in training load and intensity lead to injury which leads to inconsistent training. DO NOT GET INJURED!
    • “I’m not what I was” — so true. I can't train like I used to because I can’t recover as quickly. (And don’t have as much time?)... and my body doesn’t respond to stimulus as well as it used to either...ergo, I'm not what I was.
    • What to consider for improved recovery? Sleep, adequate protein, adequate carbohydrate fueling, hot/cold exposure, hydration, hypoxia exposure. Dr Egan likes a hot bath (me too).
    • Testosterone falling? What else isn’t what it was? How important to get back to more youthful function of the body?
    • Balancing calories surplus against calorie deficit. Keep fat and protein steady; ramp carbs to match activity (“fuel for the work required")
    • Protein load: active older athletes probably don’t have anabolic resistance. May not need extra protein for age but probably do need extra for extra exercise. (1.5-1.6g/kg per day). It’s not a silver bullet of course.
    • Collagen for tendons? It can t hurt. Get collagen into bloodstream right before (30 min?) workouts. Wallsits might help.
    • Periodization of training. (3-5 weeks cycles). Keep it fun. Cover your bases. Build in time for recovery day to day as well as deep recovery every few weeks.
    • Minimum effective dose? What is the least attention I can put into an area of fitness to keep it alive. Is there Inverted U shaped curve for fitness. More is better but too much is possible. Is that true? Too little time in other key elements of fitness?
    • Performance vs. health and athletic longevity: with time and recovery constraints, older athletes in particular have serious limitations. If you put too much into one area of athleticism, you necessarily have to neglect others. ...
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    1 h et 9 min
  • #177 | Bodycomp FMD | Renee Fitton MS RD
    Feb 3 2026

    Professional Supplements for Wise Athletes (click to see the "always on" discount)

    Renee Fitton MS RD
    • Renee is a Longevity Dietitian (she holds a masters degree in longevity nutrition earned with Dr Longo at UCLA) and she is the Director of Education at L-Nutra, the ProLon FMD company
    Using Fasting-Mimicking Diet (FMD) to manage body comp
    • I’m not alone in my struggle to build muscle while reducing body fat. I recently completed an 18 month effort to do just that starting and ending with a Dexa scan to avoid any self deception. The results were not bad (16 —> 15% body) but I did not achieve my goal (I had essentially zero muscle growth and lost no visceral fat). I have always struggled with balancing calorie surplus (for recovery and adaption to exercise), with calorie deficit for body composition and achieving my goal of zero visceral fat. I guess I need more help, eh?
    • In my talk with Renee we explore the topic of finding the minimum calorie and protein consumption (over time; not everyday) needed for the life I, you, anyone may want,
    • And the use of cycles of growth (calorie surplus, high protein, hard exercise overload) and then rejuvenation (calorie deficit, low protein, fat loss, autophagy, mitophagy) to find the path that preserves vitality and health and builds a platform for a good life.
    • The devil is in the details but in my mind the key is avoiding becoming addicted to the parts that makes us feel good about ourselves: the group we belong to, the way we look, the feeling of accomplishing something important. Such addiction leads to short term misallocation of invested time which leads to long term straying from the selected path. This is my own battle.
    Episode Resources
    • fittennutrition.com
    Related episodes & links:
    • Episode 142 | Balance Muscle & Longevity w/FMD | Joseph Antoun MD PhD
    • Episode 137 | #1 Secret to Healthy Fat Loss | Vyvyane Loh MD
    • Episode 135 | What's Your Healthy Fat%? | Vyvyane Loh MD
    • Episode 144 | Muscle for Athletic Performance | Mark Tarnopolsky MD PhD
    Help the show:

    3 ways to support our show:

    • Leave a review (or share this episode)
    • Check out our Fullscript site to save big on high quality supplements. Thank you!
    • Email us your questions at info@wiseathletes.com.
    Voir plus Voir moins
    51 min
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