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From insulin comas and lobotomy to incarceration and exile, Walter Brown chronicles the troubling history of the diagnosis and (often ineffective) treatment of bipolar disorder through the centuries, before the publication of a groundbreaking research paper in 1949. Cade's "Lithium Salts in the Treatment of Psychotic Excitement" described, for the first time, lithium's astonishing efficacy at both treating and preventing the recurrence of manic-depressive episodes, and would eventually transform the lives of patients, pharmaceutical researchers, and practicing physicians worldwide.

The search to find medicines is as old as disease, which is to say as old as the human race. Through serendipity - by chewing, brewing, and snorting - some Neolithic souls discovered opium, alcohol, snakeroot, juniper, frankincense, and other helpful substances. Ötzi the Iceman, the 5,000-year-old hunter frozen in the Italian Alps, was found to have whipworms in his intestines and Bronze Age medicine, a worm-killing birch fungus, knotted to his leggings.

Naval Ravikant is an entrepreneur, philosopher, and investor who has captivated the world with his principles for building wealth and creating long-term happiness. The Almanack of Naval Ravikant is a collection of Naval’s wisdom and experience from the last 10 years, shared as a curation of his most insightful interviews and poignant reflections. This isn’t a how-to book, or a step-by-step gimmick. Instead, through Naval’s own words, you will learn how to walk your own unique path toward a happier, wealthier life.

Growing up in the high desert of California, Jim Doty was poor, with an alcoholic father and a mother chronically depressed and paralyzed by a stroke. Today he is the director of the Center for Compassion and Altruism Research and Education (CCARE) at Stanford University, of which the Dalai Lama is a founding benefactor. But back then his life was at a dead end until at twelve he wandered into a magic shop looking for a plastic thumb. Instead he met Ruth, a woman who taught him a series of exercises to ease his own suffering and manifest his greatest desires.

Israel Meir Lau, one of the youngest survivors of Buchenwald, was just eight years old when the camp was liberated in 1945. Descended from a 1,000-year unbroken chain of rabbis, he grew up to become Chief Rabbi of Israel--and like many of the great rabbis, Lau is a master storyteller. Out of the Depths is his harrowing, miraculous, and inspiring account of life in one of the Nazis' deadliest concentration camps, and how he managed to survive against all possible odds.

For six years Jim and Jamie Dutcher lived intimately with a pack of wolves, gaining their trust as no one has before. In this book the Dutchers reflect on the virtues they observed in wolf society and behavior. Each chapter exemplifies a principle, such as kindness, teamwork, playfulness, respect, curiosity, and compassion. Their heartfelt stories combine into a thought-provoking meditation on the values shared between the human and the animal world.

Food has always been an integral part of Stanley Tucci’s life: from stracciatella soup served in the shadow of the Pantheon, to marinara sauce cooked between scene rehearsals and costume fittings, to home-made pizza eaten with his children before bedtime. Now, in What I Ate in One Year Tucci records twelve months of eating—in restaurants, kitchens, film sets, press junkets, at home and abroad, with friends, with family, with strangers, and occasionally just by himself.

In today's world, when toxic work environments and disengaged employees are all too typical, it is imperative that leaders adopt a leadership strategy that is transformative. The visionary business coach, entrepreneur, and podcast presenter Lyndsay Dowd is on a quest to revolutionize the landscape of leadership. She is also a podcast presenter. Talk to her. In light of the fact that the period of intimidation and aggressiveness has come to an end, Lyndsay is a proponent of the key components of successful leadership, which are psychological safety, connection, and cooperation.

Inspired by Albert Einstein's theory of relativity and Bertrand Russell and David Hilbert's pursuit of the fundamental rules of mathematics, some of the most brilliant minds of the generation came together in post-World War I Vienna to present the latest theories in mathematics, science, and philosophy and to build a strong foundation for scientific investigation. Composed of such luminaries as Kurt Gödel and Rudolf Carnap, and stimulated by the works of Ludwig Wittgenstein and Karl Popper, the Vienna Circle left an indelible mark on science.

In the late 1930s, legendary financier, philanthropist, and society figure Alfred Lee Loomis gathered the most visionary scientific minds of the 20th century at his state-of-the-art laboratory in Tuxedo Park, New York. He established a top-secret defense laboratory at MIT and personally bankrolled pioneering research into new, high-powered radar detection systems that helped defeat the German Air Force and U-boats. With Ernest Lawrence, he pushed Franklin Delano Roosevelt to fund research in nuclear fission, which led to the development of the atomic bomb.

Dr. Johnson may have been correct in saying that “Rousseau was a very bad man,” but none can argue that his ideas are among the most influential in all of world history. It was Rousseau, the father of the romantic movement, who was responsible for introducing at least two modern day thoughts that pervade academia. The Confessions is Rousseau’s landmark autobiography. Both brilliant and flawed, it is nonetheless beautifully written and remains one of the most moving human documents in all of literature.

Pulitzer Prize winner Wallace Stegner recounts the remarkable career of Major John Wesley Powell, the distinguished ethnologist and geologist who explored the Colorado River, the Grand Canyon, and the homeland of the Southwest Indian tribes. This classic work is a penetrating and insightful study of the Powell’s career, from the beginning of the Powell Survey, in which Powell and his men famously became the first to descend the Colorado River, to his eventual expulsion from the Geological Survey.

In this compelling memoir, Jane Hawking relates the inside story of her extraordinary marriage. As Stephen's academic renown soared, his body was collapsing under the assaults of motor neurone disease, and Jane's candid account of trying to balance his 24-hour care with the needs of their growing family is inspirational. This is a book about optimism, love and change that will resonate with listeners everywhere.

In The Deal Maker, he sheds light on a man whose tireless optimism led to the formation of the first super-corporation. A charismatic salesman in the late 19th century, William Durant started a cart-building business after accepting an especially comfortable ride one day. By the time he turned 40, he was a millionaire wondering what to do with the rest of his life.

In 2001, Sharon Pincott traded her privileged life as a high-flying corporate executive to start a new one with the Presidential Elephants of Zimbabwe. She was unpaid, untrained, self-funded, and arrived with the starry-eyed idealism of most foreigners during early encounters with Africa. For 13 years - the worst in Zimbabwe's volatile history - this intrepid Australian woman lived in the Hwange bush fighting for the lives of these elephants, forming an extraordinary and life-changing bond with them.

Shakespeare professor and prison volunteer Laura Bates thought she had seen it all. That is, until she decided to teach Shakespeare in a place the bard had never been before - supermax solitary confinement. In this unwelcoming place, surrounded by inmates known as the worst of the worst, is Larry Newton.

In Beer School, authors and entrepreneurs Steve Hindy and Tom Potter share the improbable saga of Brooklyn Brewery, the company they grew from a home-brew hobby into a multimillion-dollar business - all in the most competitive beer market in the United States. If you have a thirst for entrepreneurial success, drink up. If you are a business manager or owner and want fresh ideas and insight, tap in. You'll learn entrepreneurial basics, plus some things textbooks don't teach you, as you follow the company's successes (and a few failures).

Stanley Tucci grew up in an Italian American family that spent every night around the kitchen table. He shared the magic of those meals with us in The Tucci Cookbook and The Tucci Table, and now he takes us beyond the savory recipes and into the compelling stories behind them.​ Taste is a reflection on the intersection of food and life, filled with anecdotes about his growing up in Westchester, New York.

Why we think it’s a great listen: You thought he was a stodgy scientist with funny hair, but Isaacson and Hermann reveal an eloquent, intense, and selfless human being who not only shaped science with his theories, but politics and world events in the 20th century as well. Based on the newly released personal letters of Albert Einstein, Walter Isaacson explores how an imaginative, impertinent patent clerk became the mind reader of the creator of the cosmos.

How big is the universe? In the early twentieth century, scientists took sides. One held that the entire universe was contained in the Milky Way galaxy. Their champion was the strong-willed astronomer Harlow Shapley. Another camp believed that the universe was so vast that the Milky Way was just one galaxy among billions—the view that would prevail, proven by the equally headstrong Edwin Hubble.