Biological Technology

Nano Comes to Life opens a window onto the nanoscale - the infinitesimal realm of proteins and DNA where physics and cellular and molecular biology meet - and introduces listeners to the rapidly evolving nanotechnologies that are allowing us to manipulate the very building blocks of life. Sonia Contera gives an insider's perspective on this new frontier, revealing how nanotechnology enables a new kind of multidisciplinary science that is poised to give us control over our own biology, our health, and our lives.

The United States is embarking on a medical revolution. Supporters of personalized, or precision, medicine—the tailoring of health care to our genomes—have promised to usher in a new era of miracle cures. Advocates of this gene-guided health-care practice foresee a future where skyrocketing costs can be curbed by customization and unjust disparities are vanquished by biomedical breakthroughs. Progress, however, has come slowly, and with a price too high for the average citizen.

John C. Kendrew (1917-1997) was a pioneer in structural biology and a catalyst for the emergence of molecular biology in the second half of the 20th century. He was the first person to determine the three-dimensional structure of a protein at atomic resolution and, for this, was awarded the Nobel Prize in Chemistry in 1962. Kendrew ultimately became an international organizer, administrator, and advocate for science, and his expansive legacy lives on today.

In September 1838, a young Englishman named Charles Darwin hit upon the idea that "natural selection" among competing individuals would lead to wondrous adaptations and species diversity. Twenty-one years passed between that epiphany and publication of On the Origin of Species. The human drama and scientific controversy of that time constitute a fascinating, tangled tale that illuminates this cautious naturalist who sparked an intellectual revolution.

Survival of the fittest or survival of the nicest? Since the dawn of time man has contemplated the mystery of altruism, but it was Darwin who posed the question most starkly. From the selfless ant to the stinging bee to the man laying down his life for a stranger, evolution has yielded a goodness that in theory should never be. Set against the sweeping tale of 150 years of scientific attempts to explain kindness, The Price of Altruism tells for the first time the moving story of the eccentric American genius George Price (1922-1975), as he strives to answer evolution's greatest riddle.

Jailed as a scapegoat for Stalin's famines, Vavilov had traveled over five continents, collected hundreds of thousands of seeds in an effort to outline the ancient centers of agricultural diversity. Gary Paul Nabhan weaves together Vavilov's story with his own expeditions to Earth's richest agricultural landscapes and the cultures that tend them.

The Secret Body is a gripping drama of discovery and a landmark account of the dawning revolution in human health that reveals a hitherto invisible universe within each of us.

Jonathan Weiner, winner of the Pulitzer Prize for The Beak of the Finch, brings his brilliant reporting skills to the story of Seymour Benzer, the Brooklyn-born maverick scientist whose study of genetics and experiments with fruit fly genes has helped revolutionize or knowledge of the connections between DNA and behavior both animal and human.

Biomimicry, the science of employing nature to advance sustainable technology, is arguably one of the hottest new business concepts. At the center of this growing movement has been award-winning inventor and biomimetic entrepreneur Jay Harman.

Revealed for the first time in Racing for the Bomb, Groves played a crucial and decisive role in the planning, timing, and targeting of the Hiroshima and Nagasaki missions. Norris offers new insights into the complex and controversial questions surrounding the decision to drop the bomb in Japan and Groves' actions during World War II, which had a lasting imprint on the nuclear age and the Cold War that followed.

We all make mistakes. Nobody’s perfect. Not even some of the greatest geniuses in history, as Mario Livio tells us in this marvelous story of scientific error and breakthrough. Charles Darwin, William Thomson (Lord Kelvin), Linus Pauling, Fred Hoyle, and Albert Einstein were all brilliant scientists. Each made groundbreaking contributions to his field - but each also stumbled badly. These five scientists expanded our knowledge of life on Earth, the evolution of the Earth itself, and the evolution of the universe, despite and because of their errors. As Mario Livio luminously explains, the scientific process advances through error.

Charles Darwin is arguably the most influential scientist of all time. His Origin of Species forever changed our concept of the world’s creation. Darwin’s revolutionary career is the perfect vehicle for historian Paul Johnson. Marked by the insightful observation, spectacular wit, and highly readable prose for which Johnson is so well regarded, Darwin brings the gentleman-scientist and his times brilliantly into focus. From Darwin’s birth into great fortune to his voyage aboard the Beagle, to the long-delayed publication of his masterpiece, Johnson delves into what made this Victorian gentleman into a visionary scientist.

James T. Costa takes listeners on a journey from Darwin's youth and travels on the HMS Beagle to Down House, his bustling home of 40 years. We accompany Darwin in his myriad pursuits against the backdrop of his enduring marriage, chronic illness, grief at the loss of three children, and joy in scientific revelation. At each chapter's end, Costa shows how we, too, can investigate the wonders of nature at work, with directions on how to re-create Darwin's experiments.

Imagine living in a world where people use their computers, drive their cars, and communicate with one another simply by thinking. In this stunning and inspiring work, Duke University neuroscientist Miguel Nicolelis shares his revolutionary insights into how the brain creates thought and the human sense of self - and how this might be augmented by machines, so that the entire universe will be within our reach.

Bill McKibben, examines the dangers inherent in an array of technologies that threaten not just our survival, but our identity. Imagine a future where lab workers can reprogram human embryos to make our children "smarter" or "more sociable" or "happier." Enough examines such possibilities, and explains how we can avoid their worst consequences while still enjoying the fruits of our new scientific understandings.

The award-winning journalist Lisa Margonelli investigates the environmental and economic impact termites inflict on human societies in this fascinating examination of one of nature's most misunderstood insects.

If you think sexism thrives only on Wall Street or Hollywood, you haven’t visited a lab, a science department, a research foundation, or a biotech firm. Rita Colwell is one of the top scientists in America: the groundbreaking microbiologist who discovered how cholera survives between epidemics and the former head of the National Science Foundation. But when she first applied for a graduate fellowship in bacteriology, she was told, “We don’t waste fellowships on women.” A lack of support from some male superiors would lead her to change her area of study six times.

The Age of Living Machines describes some of the most exciting new developments and the scientists and engineers who helped create them. Virus-built batteries. Protein-based water filters. Cancer-detecting nanoparticles. Mind-reading bionic limbs. Computer-engineered crops. Together they highlight the promise of the technology revolution of the 21st century to overcome some of the greatest humanitarian, medical, and environmental challenges of our time.

In Life Finds a Way, biologist Andreas Wagner reveals the deep symmetry between innovation in biological evolution and human cultural creativity. Rarely is either a linear climb to perfection - instead, "progress" is typically marked by a sequence of peaks, plateaus, and pitfalls. For instance, in Picasso's 40-some iterations of Guernica, we see the same combination of small steps, incessant reshuffling, and large, almost reckless, leaps that characterize the way evolution transformed a dinosaur's grasping claw into a condor's soaring wing.

Biomimetics literally means emulating biology—and in a broader sense the term covers technological advances where the original inspiration came from nature. The Earth is a vast laboratory where the mechanisms of natural selection have enabled evolutionary solutions to be developed to a wide range of problems. Science writer Brian Clegg looks at how humans have piggybacked on natural experimentation, redeploying a solution to create things that make our lives easier.