Health Care History

The first major bioterror event in the United States - the anthrax attacks in October 2001 - was a clarion call for scientists who work with “hot” agents to find ways of protecting civilian populations against biological weapons. In The Demon in the Freezer, Richard Preston takes us into the heart of USAMRIID, the United States Army Medical Research Institute of Infectious Diseases at Fort Detrick, Maryland, once the headquarters of the US biological weapons program and now the epicenter of national biodefense.

In Longshot, investigative journalist David Heath takes listeners inside the small group of scientists whose groundbreaking work was once largely dismissed but whose feat will now eclipse the importance of Jonas Salk’s polio vaccine in medical history. With never-before-reported details, Heath reveals how these scientists overcame countless obstacles to give the world an unprecedented head start when we needed a COVID-19 vaccine.

Medicines are arguably the most highly regulated - and cost-inflated - products in the United States. The discovery, development, manufacturing, and distribution of medicines is carried out by an ever more complex and crowded set of industries, each playing a part in a larger “pharmaceutical enterprise” seeking to maximize profits. But this was not always the case. The Price of Health is the reveals the story of how the pharmaceutical enterprise took shape and led to the present crisis.

In 1866, 12 men and women and one small child were forced aboard a leaky schooner and cast away to a natural prison on the Hawaiian island of Molokai. Two weeks later, a dozen others were exiled, and then 40 more, and then 100 more. Tracked by bounty hunters and torn screaming from their families, the luckless were loaded into shipboard cattle stalls and abandoned in a lawless place where brutality held sway. Many did not have leprosy, and most of those who did were not contagious.

In the early 1960s, Dr. Frances Oldham Kelsey of the U.S. Food and Drug Administration became one of the most celebrated women in America when she prevented a deadly sedative from entering the U.S. market. A Canadian-born pharmacologist and physician, Kelsey saved countless Americans from the devastating side effects of thalidomide, routinely given to pregnant women to prevent morning sickness. As the FDA medical officer charged with reviewing Merrell Pharmaceutical’s application for approval, Kelsey was unconvinced that there was sufficient evidence of the drug’s efficacy and safety.

In 1932, the US Public Health Service recruited 623 African American men from Macon County, Alabama, for a study of "the effects of untreated syphilis in the Negro male". For the next 40 years - even after the development of penicillin, the cure for syphilis - these men were denied medical care for this potentially fatal disease.

Seamus O'Mahony writes about the illusion of progress, the notion that more and more diseases can be "conquered" ad infinitum. He punctures the idiocy of consumerism, the idea that healthcare can be endlessly adapted to the wishes of individuals. He excoriates the claims of Big Science, the spending of vast sums on research follies like the Human Genome Project. And he highlights one of the most dangerous errors of industrialized medicine: an over-reliance on metrics, and a neglect of things that can't easily be measured, like compassion.

Since 2010, it has been possible to determine a person's genetic makeup in a matter of days at an accessible cost for many millions of people. Along with this technological breakthrough there has emerged a movement to use this information to help prospective parents "eliminate preventable genetic disease". As the prospect of systematically excluding the appearance of unwanted mutations in our children comes within reach, David B. Goldstein examines the possible consequences from these types of choices.

In the 1970s, a small group of leading psychiatrists met behind closed doors and literally rewrote the book on their profession. Revising and greatly expanding the Diagnostic and Statistical Manual of Mental Disorders (DSM for short), they turned what had been a thin, spiral-bound handbook into a hefty tome. Almost overnight the number of diagnoses exploded. The result was a windfall for the pharmaceutical industry and a massive conflict of interest for psychiatry at large.

It is 1919 and Elizabeth Hughes, the 11-year-old daughter of America's most-distinguished jurist and politician, Charles Evans Hughes, has been diagnosed with juvenile diabetes. It is essentially a death sentence. The only accepted form of treatment - starvation - whittles her down to 45 pounds, skin and bones. Miles away, Canadian researchers Frederick Banting and Charles Best manage to identify and purify insulin from animal pancreases - a miracle soon marred by scientific jealousy, intense business competition, and fistfights.

Oxford Case Histories in Infection and Microbiology contains over 45 well structured cases, providing comprehensive coverage of the diagnostic and management dilemmas in clinical microbiology and infectious diseases. Each case comprises of a brief patient history with relevant clinical examination findings, thus insuring the listener is aware of how to confirm a diagnosis rapidly, with reference throughout to laboratory techniques, advice on therapy, epidemiological features, and areas which can be controversial.

Measles, once seemingly defeated, is resurgent around the globe. Why, at a time when biomedical science is so advanced, do parents turn away from vaccination, endangering their own children and the health of the wider population? Using a combination of patient narrative, historical analysis, and scientific research, Dr. Adam Ratner, pediatrician and infectious disease specialist, argues that the reawakening of measles and the subsequent coronavirus pandemic are bellwethers of forgotten knowledge—indicators of decaying trust in science and an underfunded public health infrastructure.

For Chinese immigrant Wong Chut King, surviving in San Francisco meant a life in the shadows. His passing on March 6, 1900, would have been unremarkable if a city health officer hadn't noticed a swollen black lymph node on his groin - a sign of bubonic plague. Empowered by racist pseudoscience, officials rushed to quarantine Chinatown while doctors examined Wong's tissue for telltale bacteria. If the devastating disease was not contained, San Francisco would become the American epicenter of an outbreak that had already claimed 10 million lives worldwide.

A Silent Spring for the human body, this wide-ranging, genre-crossing literary mystery interweaves the author’s quest to understand the source of her own condition with her telling of the story of the chronically ill 19th-century diarist Alice James—ultimately uncovering the many hidden health hazards of life in America.

No disease sparked as much dread in the 18th century as smallpox. The virus killed millions across the globe, carrying off one in every five victims and disfiguring survivors with tell-tale pitted scars. But one mysterious method offered hope: inoculation, the practice of piercing the skin to insert a drop of infected matter and induce a mild case of smallpox. Those inoculated safely were protected from the ‘Speckled Monster’ and stayed immune for life. Only one problem remained: convincing people to accept the treatment.

A History of the World in Six Plagues shows that throughout history, outbreaks of disease have been exacerbated by and gone on to further expand the racial, economic, and sociopolitical divides we allow to fester in times of good health. Princeton-trained historian Edna Bonhomme’s examination of humanity’s disastrous treatment of pandemic disease takes us across place and time from Port-au-Prince to Tanzania, and from plantation-era America to our modern COVID-19-scarred world to unravel shocking truths about the patterns of discrimination in the face of disease.

In this astonishing book, Mark Woolhouse recounts the history of the COVID-19 pandemic through the eyes of a scientist at the very centre of the action. He explores the failures and successes of the United Kingdom’s, and the world’s, response to the virus, shows how he briefed both the British and Scottish governments on the scale of the fight ahead and candidly describes the challenges scientists faced when working with politicians.

A riveting, fast-paced, inside look at one of the most incredible private sector achievements in history, Moonshot recounts the intensive nine months in 2020 when the scientists at Pfizer, under the visionary leadership of Dr. Albert Bourla, made “the impossible possible”—creating, testing, and manufacturing a safe and effective COVID-19 vaccine that previously would have taken years to develop. Dr. Bourla chronicles how the brilliant, dedicated minds at Pfizer overcame a series of crises that were compounded by social and political unrest.

Today, 90 percent of psychiatric beds are located in jails and prisons across the United States, institutions that confine disproportionate numbers of African Americans. After more than a decade of research, the celebrated scholar and activist Mab Segrest locates the deep historical roots of this startling fact, turning her sights on a long-forgotten cauldron of racial ideology: the state mental asylum system in which psychiatry was born and whose influences extend into our troubled present.

Still Not Safe is the story of the rise of the patient - safety movement - and how an "epidemic" of medical errors was derived from a reality that didn't support such a characterization. Physician Robert Wears and organizational theorist Kathleen Sutcliffe trace the origins of patient safety to the emergence of market trends that challenged the place of doctors in the larger medical ecosystem.