Human Genetics

Homo sapiens emerged as a species about 200,000 years ago and soon—with fire, simple tools, and an egalitarian social system—we inhabited every continent. But now our infinitely elaborated tools and our highly non-egalitarian social system threaten sustainability. Many at the bottom lose the desire to live, committing suicide or succumbing to drugs, alcohol, and obesity. What is Health? explains from the bottom up—molecules to society—how we reached this point.

Scientists' understanding of life is progressing more rapidly than at any point in human history, from the extraordinary decoding of DNA to the controversial emergence of biotechnology. Featuring pioneering biologists, geneticists, physicists, and science writers, Life explains just how far we've come - and takes a brilliantly educated guess at where we're heading.

Nicolelis undertakes the first attempt to explain the entirety of human history, culture, and civilization based on a series of recently uncovered key principles of brain function. This new cosmology is centered around three fundamental properties of the human brain: its insurmountable malleability to adapt and learn; its exquisite ability to allow multiple individuals to synchronize their minds around a task, goal, or belief; and its incomparable capacity for abstraction.

How did humans come to be who we are? In his marvelous, eccentric, and widely lauded book Being a Beast, legal scholar, veterinary surgeon, and naturalist extraordinaire Charles Foster set out to understand the consciousness of animal species by living as a badger, otter, fox, deer, and swift. Now, he inhabits three crucial periods of human development to understand the consciousness of perhaps the strangest animal of all—the human being.

The Secret Body is a gripping drama of discovery and a landmark account of the dawning revolution in human health that reveals a hitherto invisible universe within each of us.

Humans are awesome. Our brains are gigantic, seven times larger than they should be for the size of our bodies. The human brain uses 25 percent of all the energy the body requires each day. And it became enormous in a very short amount of time in evolution, allowing us to leave our cousins, the great apes, behind. So the human brain is special, right? Wrong, according to Suzana Herculano-Houzel. Humans have developed cognitive abilities that outstrip those of all other animals but not because we are evolutionary outliers.

Fifty thousand years ago - merely a blip in evolutionary time - our Homo sapiens ancestors were competing for existence with several other human species, just as their precursors had done for millions of years. Yet something about our species distinguished it from the pack, and ultimately led to its survival while the rest became extinct. Just what was it that allowed Homo sapiens to become masters of the planet? Ian Tattersall, curator emeritus at the American Museum of Natural History, takes us deep into the fossil record to uncover what made humans so special.

Pets have never been more popular. Over half of American households share their home with either a cat or a dog, and many contain both. This is a huge change from only a century ago, when the majority of domestic cats and dogs were working animals, keeping rodents at bay, guarding property, herding sheep. Nowadays, most are valued solely for the companionship they provide. As mankind becomes progressively more urban and detached from nature, we seem to be clinging to the animals that served us well in the past.

The story of how our ancestors made the first tentative steps towards becoming human, how we lost our fur but gained language, fire and tools, and how we strode out of Africa, invented farming and cities and ultimately created modern civilisation. Where did we come from? Where are we going? Homo sapiens is the most successful, the most widespread and the most influential species ever to walk the Earth.

It feels like a fairy tale when Alberta ”Bert” Monte receives a letter addressed to “Countess Alberta Montebianco” at her Hudson Valley, New York, home that claims she’s inherited a noble title, money, and a castle in Italy. While Bert is more than a little skeptical, the mystery of her aristocratic family’s past, and the chance to escape her stressful life for a luxury holiday in Italy, is too good to pass up.

Humans, it turns out, are intrinsically wired to seek short-term success at the expense of long-term prosperity. Kristian Rönn, an entrepreneur formerly affiliated with the University of Oxford’s Future of Humanity Institute, calls these deeply rooted impulses “Darwinian demons.” These forces, a by-product of natural selection, can lead us to act in shortsighted ways that harm others—and even imperil our survival as a species. If this evolutionary glitch is left unchecked, the consequences will grow in magnitude as the power of technology accelerates.

Our species has amassed unprecedented knowledge of nature, which we have tried to use to seize control of life and bend the planet to our will. In A Natural History of the Future, biologist Rob Dunn argues that such efforts are futile. We may see ourselves as life’s overlords, but we are instead at its mercy. In the evolution of antibiotic resistance, the power of natural selection to create biodiversity, and even the surprising life of the London Underground, Dunn finds laws of life that no human activity can annul.

Generations have been taught that evolution implies there is no overarching purpose to our existence. Some scientists take this logic one step further, suggesting that evolution is intrinsically atheistic and goes against the concept of God. But is this true? By integrating emerging principles from a variety of scientific disciplines—ranging from evolutionary biology to psychology—Yale Professor Samuel Wilkinson provides a framework of evolution that implies not only that there is an overarching purpose to our existence, but what this purpose is.

A Pocket History of Human Evolution brings us up-to-date on the exploits of all our ancient relatives. Paleoanthropologist Silvana Condemi and science journalist François Savatier consider what accelerated our evolution: Was it tools, our "large" brains, language, empathy, or something else entirely? And why are we the sole survivors among many early bipedal humans? Their conclusions reveal the various ways ancient humans live on today - from gossip as modern "grooming" to our gendered division of labor - and what the future might hold for our strange and unique species.

For all that science knows about the living world, notes David P. Barash, there are even more things we don't know, genuine evolutionary mysteries that perplex the best minds in biology. Paradoxically, many of these mysteries are very close to home, involving some of the most personal aspects of being human. Homo Mysterious examines a number of these evolutionary mysteries, exploring things we don't yet know about ourselves, laying out the best current hypotheses, and pointing toward insights that scientists are just beginning to glimpse.

The United States is embarking on a medical revolution. Supporters of personalized, or precision, medicine—the tailoring of health care to our genomes—have promised to usher in a new era of miracle cures. Advocates of this gene-guided health-care practice foresee a future where skyrocketing costs can be curbed by customization and unjust disparities are vanquished by biomedical breakthroughs. Progress, however, has come slowly, and with a price too high for the average citizen.

Resistance to malaria. Blue eyes. Lactose tolerance. What do all of these traits have in common? Every one of them has emerged in the last 10,000 years.

Darwin considered humans one part of the web of life, not the apex of a natural hierarchy. Yet today many maintain that we are the most intelligent, virtuous, successful species that ever lived. This flawed thinking enables us to exploit the earth towards our own exclusive ends, throwing us into a perilous planetary imbalance. But is this view and way of life inevitable? The Arrogant Ape shows that human exceptionalism is an ideology that relies more on human culture than our biology, more on delusion and faith than on evidence.

Mike Cohen has it all figured out. A successful venture capitalist, he’s got billions in the bank, a lifestyle any New Yorker would kill for, and - if he plays his cards right - a shot with his cute, punky coworker. But everything changes when the life-altering technology he's developing lands him in the middle of a global conspiracy, and the only way to save himself, his loved ones, and his tech is to embed the highly experimental Brainocytes in his own brain. Brainocytes transform the human experience, making you smarter, faster, and more powerful.

We’ve come a long way. The earliest human had a brain as small as a child’s fist; ours are four times bigger, with spectacular abilities and potential we are only just beginning to understand. This is How the Mind Changed, a seven-million-year journey through our own heads, packed with vivid stories, groundbreaking science, and thrilling surprises. Discover how memory has almost nothing to do with the past.