Medical History

Ingrassia lost his mother, two sisters, brother, and nephew to cancer—different cancers developing at different points throughout their lives. And while highly unusual, his family is not the only one to wonder whether their heartbreak is the result of unbelievable bad luck, or if there might be another explanation. Through meticulous research and riveting storytelling, Ingrassia takes us from the 1960s—when Dr. Frederick Pei Li and Dr. Joseph Fraumeni Jr. first met, not yet knowing that they would help make a groundbreaking discovery that would affect cancer patients for decades to come.

For centuries, the human heart seemed beyond our understanding: an inscrutable shuddering mass that was somehow the driver of emotion and the seat of the soul. As cardiologist and best-selling author Sandeep Jauhar tells in The Heart, it was only recently that we demolished age-old taboos and devised the transformative procedures that changed the way we live. Deftly alternating between historical episodes and his own work, Jauhar tells the colorful and little known story of the doctors who risked their careers and the patients who risked their lives to know and heal our most vital organ.

Dr. Aribert Heim worked at the Mauthausen concentration camp for only a few months in 1941 but left a devastating mark. According to the testimony of survivors, Heim euthanized patients with injections of gasoline into their hearts. He performed surgeries on otherwise healthy people. Some recalled prisoners' skulls set out on his desk to display perfect sets of teeth. Yet in the chaos of the postwar period, Heim was able to slip away from his dark past and establish himself as a reputable doctor and family man in the resort town of Baden-Baden.

Considering herself unsuitable for any other contribution to the war effort, Monica Dickens opts for nursing, imagining herself gliding through the wards, serene in a pure white halo cap. On enrolment, however, she is promptly stripped of all illusions. Intelligent and headstrong, Monica struggles to submit to the iron rule of the Matron and toils over the mountains of menial work that are a trainee's lot. But there are friends among the staff and patients, night-time escapades to dances with dashing army men and her secret writing project to keep her going.

In the last half of the twentieth century, Don Thomas discovered a cure for every marrow-based disease—like leukemia, lymphoma, and sickle-cell anemia—forever changing treatment for some of the deadliest illnesses. His feats were extraordinary, earning him a Nobel Prize, and the cascade of treatments he inspired have reshaped and will continue to reshape the practice of clinical medicine. Yet no one has ever written Thomas’s courageous story.Dr. Frederick R. Appelbaum, a member of Thomas’s research team, does so for the first time.

Based on the film by acclaimed documentary filmmaker Ken Burns, The Mayo Clinic: Faith, Hope, Science chronicles the history of this unique organization, from its roots as an unlikely partnership between a country doctor and a Franciscan order of nuns to its position today as a worldwide model for patient care, research, and education. The book demonstrates how the institution’s remarkable 150-year history continues to inspire the way medicine is practiced there today.

An estimated 10 percent of Americans are implanted with medical devices - like pacemakers, artificial hips, cardiac stents, etc. The overwhelming majority of high-risk implanted devices have never undergone a single clinical trial. The FDA lets device manufacturers decide whether to report serious complications or deaths that may have been caused by their products. Here, award-winning journalist Jeanne Lenzer brings these horrifying statistics to life through the story of one working-class man who, after his "cure" nearly kills him, ends up in a battle for justice.

Galen of Pergamum (A.D. 129-ca. 216) began his remarkable career tending to wounded gladiators in provincial Asia Minor. Later in life he achieved great distinction as one of a small circle of court physicians to the family of Emperor Marcus Aurelius, at the very heart of Roman society. Susan Mattern's The Prince of Medicine offers the first authoritative biography in English of this brilliant, audacious, and profoundly influential figure.

As scientists confidently look forward to average life expectancies hitting 100+ years in some Western societies, it’s easy to forget how precarious our grasp on good health has been. It is a struggle no better demonstrated than by the myriad and extraordinary measures that humans have gone to – as diverse as animal sacrifice to stem cell transplants – in their quest to stave off death and disease. Acclaimed historian Mark Jackson takes a fresh global view of mankind’s great battle, exploring both Western and Eastern traditions.

Ever since the 1918 Spanish influenza pandemic, scientists have dreamed of preventing catastrophic outbreaks of infectious disease. Yet despite a century of medical progress, viral and bacterial disasters continue to take us by surprise, inciting panic and dominating news cycles. From the Spanish flu to the 1924 outbreak of pneumonic plague in Los Angeles to the 1930 "parrot fever" pandemic, through the more recent SARS, Ebola, and Zika epidemics, the last one hundred years have been marked by a succession of unanticipated pandemic alarms.

In 1959, a Cincinnati pharmaceutical firm, the William S. Merrell Company, quietly began distributing samples of an exciting new wonder drug already popular around the world. Touted as a sedative without risks, thalidomide was handed out freely, under the guise of clinical trials, by doctors who believed approval by the Food and Drug Administration was imminent. But in 1960, when the application for thalidomide landed on the desk of FDA medical reviewer Frances Kelsey, she quickly grew suspicious.

Patti Davis, the daughter of Ronald and Nancy Reagan, writes about losing her father to Alzheimer's disease, saying goodbye in stages, and watching the progression of a disease that steals what is most precious: a person's memory. Past and present come together in this illuminating portrait of grief, of a man, a disease, and a girl and her father.

It wasn’t supposed to be this hard. If America could send a man to the moon, shouldn’t the best surgeons in the world be able to build an artificial heart? In Ticker, Texas Monthly executive editor and two time National Magazine Award winner Mimi Swartz shows just how complex and difficult it can be to replicate one of nature’s greatest creations. Part investigative journalism, part medical mystery, Ticker is a dazzling story of modern innovation, recounting 50 years of false starts, abysmal failures, and miraculous triumphs.

Metabolism, behavior, sleep, mood swings, the immune system, fighting, fleeing, puberty, and sex: these are just a few of the things our bodies control with hormones. Armed with a healthy dose of wit and curiosity, Randi Hutter Epstein takes us on a journey through the unusual history of these potent chemicals and their discovery, from the London laboratory where the concept of hormones was identified to a basement filled with jarred brains to a canine sex lab.

In the early 1800s, a century before there was any concept of the gene, physicians in insane asylums began to record causes of madness in their admission books. Almost from the beginning, they pointed to heredity as the most important of these causes. As doctors and state officials steadily lost faith in the capacity of asylum care to stem the terrible increase of insanity, they began emphasizing the need to curb the reproduction of the insane. They became obsessed with identifying weak or tainted families and anticipating the outcomes of their marriages.

On January 12, 2010, a major earthquake struck near Port-au-Prince, Haiti. Hundreds of thousands of people died, and the greater part of the capital was demolished. Dr. Paul Farmer, U.N. deputy special envoy to Haiti, who had worked in the country for nearly thirty years treating infectious diseases like tuberculosis and AIDS, and former President Bill Clinton, the U.N. special envoy to Haiti, had just begun to work on an extensive development plan to improve living conditions in Haiti.

this exciting story illuminates the captivating world of the late Renaissance - in this case its plagues, remedies, and alchemy - through the life of Leonardo Fioravanti, a brilliant, remarkably forward-thinking, and utterly unconventional doctor. Fioravanti's marvelous cures and talent for self-aggrandizement earned him the adoration of the people, the scorn of the medical establishment, and a reputation as one of the age's most colorful, combative figures.

For 200 years, a noble Venetian family has suffered from an inherited disease that strikes their members in middle age, stealing their sleep, eating holes in their brains, and ending their lives in a matter of months. In Papua New Guinea, a primitive tribe is nearly obliterated by a sickness whose chief symptom is uncontrollable laughter. Across Europe, millions of sheep rub their fleeces raw before collapsing. What these strange conditions share is their cause: prions.

Americans are in the midst of a world-historic drug binge. Opiates, amphetamines, benzodiazepines, marijuana, antidepressants, antipsychotics—across the board, consumption has shot up in the twenty-first century. At the same time, the United States is home to the largest prison system in the world, justified in part by a now zombified "war" on drugs. How did we get here?

Salk became a cultural hero and icon for a whole generation. Now, at the fiftieth anniversary of the first national vaccination program, and as humanity is tantalizingly close to eradicating polio worldwide, comes this unforgettable chronicle. Salk's work was an unparalleled achievement, and it makes for a magnificent listen.