"You don't know me yet, but in a few hours that's going to change. You see, I'm inviting you to my home and my town of Cedar Cove, because I want you to meet my family, friends, and neighbors. Come and hear their stories - maybe even their secrets!"

Wanted: Midwife/nurse practitioner in Virgin River, population 600. Make a difference against a backdrop of towering California redwoods and crystal clear rivers. Rent-free cabin included. When the recently widowed Melinda Monroe sees this ad, she quickly decides that the remote mountain town of Virgin River might be the perfect place to escape her heartache and to reenergize the nursing career she loves. But her high hopes are dashed within an hour of arriving - the cabin is a dump, the roads are treacherous, and the local doctor wants nothing to do with her.

Cassie has sworn off men after yet another bad date though, deep down, she’s still looking for Mr. Right. A long-haired, tattooed biker is definitely not him, so there’s no harm in a few Harley rides through Sonoma. Right? Julie married her high school sweetheart too young and now wonders how her life became all about leaky faucets and checkbook balances. Maybe love isn’t enough to sustain the perfect couple.

Colin Hancock is giving his second chance his best shot. At 28, he's focused only on walking a straight line - getting his teaching degree, working out at the gym religiously, and avoiding all the places and people that proved so destructive in his earlier life. The last thing he's looking for is a serious relationship. But when Maria Sanchez crosses paths with him on a rainswept night in North Carolina, his plans are upended in a way that will rattle the foundations of his carefully structured life.

Jo Marie Rose first arrives in Cedar Cove seeking a sense of peace and a fresh start. She purchases a local bed-and-breakfast - the newly christened Rose Harbor Inn - ready to begin her life anew. Yet the inn holds more surprises than Jo Marie can imagine. Her first guest is Joshua Weaver, who has come home to care for his ailing stepfather. The two have never seen eye to eye, and Joshua has little hope that they can reconcile. But a long-lost acquaintance from Joshua's high school days proves to him that forgiveness is never out of reach and love can bloom where it's least expected.