Days after being dumped by her boyfriend Marc in Paris - "he was heading off to an ashram and said we could communicate telepathically" - Hattie hears her sister Min has been checked into a psychiatric hospital, and finds herself flying back to Winnipeg to take care of Thebes and Logan, her niece and nephew. Not knowing what else to do, they set out on a road trip in search of the children's long-lost father, Cherkis. On their wayward journey, the Troutmans stay at scary motels, meet helpful hippies, and try to ignore the threatening noises coming from under the hood of their van.

Sixteen-year-old Nomi Nickel longs to hang out with Lou Reed and Marianne Faithfull in New York City's East Village. Instead she's trapped in East Village, Manitoba, a small town whose population is Mennonite: "the most embarrassing sub-sect of people to belong to if you're a teenager." East Village is a town with no train and no bar whose job prospects consist of slaughtering chickens at the Happy Family Farms abattoir or churning butter for tourists at the pioneer village.

When Garnet Raven was three years old, he was taken from his home on an Ojibway Indian reserve and placed in a series of foster homes. Having reached his mid-teens, he escapes at the first available opportunity, only to find himself cast adrift on the streets of the big city. Having skirted the urban underbelly once too often by age 20, he finds himself thrown in jail. While there, he gets a surprise letter from his long-forgotten native family. The sudden communication from his past spurs him to return to the reserve following his release from jail.

Elf and Yoli are sisters. While on the surface Elfrieda's life is enviable (she's a world-renowned pianist, glamorous, wealthy, and happily married,) and Yolandi's a mess (she's divorced and broke, with two teenagers growing up too quickly), they are fiercely close - raised in a Mennonite household and sharing the hardship of Elf's desire to end her life.

One night, while lying in bed next to her husband, Claire Devon suddenly hears a low hum. This innocuous sound, which no one else in the house can hear, has no obvious source or medical cause, but it begins to upset the balance of Claire’s life. When she discovers that one of her students can also hear the hum, the two strike up an unlikely and intimate friendship. Finding themselves increasingly isolated from their families and colleagues, they fall in with a disparate group of people who also perceive the sound.