In 1541, the brutal conquistador Gonzalo Pizarro and his well-born lieutenant Francisco Orellana set off from Quito in search of La Canela, South America's rumored Land of Cinnamon, and the fabled El Dorado, "the golden man". Driving an enormous retinue of mercenaries, enslaved natives, horses, hunting dogs, and other animals across the Andes, they watched their proud expedition begin to disintegrate even before they descended into the nightmarish jungle, following the course of a powerful river.

Steven Rinella (The MeatEater Podcast) and Clay Newcomb (MeatEater's Bear Grease podcast) gather listeners for a new round of stories, this time drawing from the lives of the rugged Long Hunters, who include such figures as Daniel Boone, Henry Skaggs, and Kasper Mansker. These were the commercial hunters and trappers who explored and exploited the First Far West, the land across the Appalachian Mountains, in the era between the Seven Years War and the American Revolution—one of the most fabled periods of American history.

In the summer of 1913, the wooden-hulled brigantine Karluk departed Canada for the Arctic Ocean. At the helm was Captain Bob Bartlett, considered the world’s greatest living ice navigator. The expedition’s visionary leader was a flamboyant impresario named Vilhjalmur Stefansson hungry for fame. Just six weeks after the Karluk departed, giant ice floes closed in around her. As the ship became icebound, Stefansson disembarked with five companions and struck out on what he claimed was a 10-day caribou hunting trip. Most on board would never see him again.

It was a moment unique in human history: the face-to-face meeting between two men from civilizations a world apart. In 1519, Hernán Cortés arrived on the shores of Mexico, determined not only to expand the Spanish empire but to convert the natives to Catholicism and carry off a fortune in gold. That he saw nothing paradoxical in his intentions is one of the most remarkable and tragic aspects of this unforgettable story.

In 1528, a mission set out from Spain to colonize Florida. But the expedition went horribly wrong: Delayed by a hurricane, knocked off course by a colossal error of navigation, and ultimately doomed by a disastrous decision to separate the men from their ships, the mission quickly became a desperate journey of survival. Of the 300 men who had embarked on the journey, only four survived - three Spaniards and an African slave.