On the surface, these seven women are as different as can be - but each has had her share of bad luck, from cheating husbands to sexist colleagues to a legal system that often doesn't do its job. Now, drawn together by tragedy, they're forging a bond that will help them right the wrongs committed against them and discover an inner strength they didn't know they had. The Sisterhood is learning that when bad things happen, you can roll over and play dead...or you can get up fighting...

For Melanie Drake, school guidance counselor in a small Virginia town, the day’s challenges typically involve a playground scuffle or a student skipping school. It’s worlds away from her previous career as a vital part of the Office of Special Investigations. There, she devoted herself heart and soul to covert operations, the riskier the better.

Luna Bodman always looks forward to a new shipment of furniture at the restoration shop. Her brother, Cullen, has a knack for finding discarded pieces with an intriguing history, and Luna likes to sit with each item to see if she can feel any kind of vibrations. Usually, Cullen does his thing while Luna does hers, but the arrival of an old armoire triggers a reaction in Luna that’s impossible to ignore. From the moment Luna wiggles inside the armoire and closes her eyes, she feels an overpowering and disturbing sensation.

Oscar-winning actress Ardith Law is a Hollywood icon. Radiant at sixty-two, she is the epitome of glamour and a highly respected artist. But her success has come at a price: she has a strained relationship with her daughter, Morgan, who at thirty-eight still blames Ardith for putting her career before being a mother. Morgan is a successful plastic surgeon in New York City—and the distance from Ardith's Bel Air mansion is not lost on either of them. Ardith became a single mother when Morgan was seven, after her unfaithful husband died in a helicopter accident.

At Ridgewood High, Amy, Frankie, Rachael, and Nina formed a deep bond. Now, 15 years after leaving school behind, they’re back for a reunion, laughing, reminiscing, and chatting how much has changed - and how much hasn’t. But Frankie has an idea to help solve that: a singles cruise for the holidays.