Pastor Jimmie Hicks Jr. emphasizes the importance of presenting ourselves as living sacrifices to God, based on Romans 12:1. He contrasts this with Old Testament dead sacrifices, highlighting that true sacrifice involves being obedient to God and living in accordance with His will. The sermon outlines that this commitment includes cultivating a spirit of gratitude and seeking God's favor in our lives through actions that reflect our faith. Ultimately, he calls on believers to recognize their relationship with God hinges on being fully devoted and living out their faith authentically.