Julia Ames, after a youth marked by upheaval and emotional turbulence, has found herself on the placid plateau of mid-life. But Julia has never navigated the world with the equanimity of her current privileged class. Having nearly derailed herself several times, making desperate bids for the kind of connection that always felt inaccessible to her, she finally feels, at age fifty seven, that she has a firm handle on things. She’s unprepared, though, for what comes next.

Daisy Shoemaker can’t sleep. With a thriving cooking business, full schedule of volunteer work, and a beautiful home in the Philadelphia suburbs, she should be content. But her teenage daughter can be a handful, her husband can be distant, her work can feel trivial, and she has lots of acquaintances, but no real friends. Still, Daisy knows she’s got it good. So why is she up all night?

Six years after the fight that ended their friendship, Daphne Berg is shocked when Drue Cavanaugh walks back into her life, looking as lovely and successful as ever, with a massive favor to ask. Daphne hasn’t spoken one word to Drue in all this time - she doesn’t even hate-follow her ex-best friend on social media - so when Drue asks if she will be her maid-of-honor at the society wedding of the summer, Daphne is rightfully speechless.

Thirty-three-year-old Abby Stern has made it to a happy place. True, she still has gig jobs instead of a career, and the apartment where she’s lived since college still looks like she’s just moved in. But she’s got good friends, her bike, and her bicycling club in Philadelphia. She’s at peace with her plus-size body—at least, most of the time—and she’s on track to marry Mark Medoff, her childhood sweetheart, a man she met at the weight-loss camp that her perpetually dieting mother forced her to attend.

Four freshmen arrive at college from completely different worlds: Lainey, a California party girl with a flair for drama; Tyson, a brilliant scholar and aspiring lawyer from Washington, D.C.; Summer, an ambitious, recruited athlete from the Midwest; and Hannah, a mild-mannered southerner who is content to quietly round out the circle of big personalities. Soon after arriving on campus, they strike up a conversation in their shared dorm, and the seeds of friendship are planted.