Julian Jessop, an eccentric, lonely artist and septuagenarian believes that most people aren’t really honest with each other. But what if they were? And so he writes—in a plain, green journal—the truth about his own life and leaves it in his local café. It’s run by the incredibly tidy and efficient Monica, who furtively adds her own entry and leaves the book in the wine bar across the street. Before long, the others who find the green notebook add the truths about their own deepest selves - and soon find each other In Real Life at Monica’s Café.

Every day Iona, a larger-than-life magazine advice columnist, travels the ten stops from Hampton Court to Waterloo Station by train, accompanied by her dog, Lulu. Every day she sees the same people, whom she knows only by nickname: Impossibly-Pretty-Constant-Reader and Terribly-Lonely-Teenager. Of course, they never speak. Seasoned commuters never do. Then one morning, the man she calls Smart-But-Sexist-Manspreader chokes on a grape right in front of her. He’d have died were it not for the timely intervention of Sanjay, a nurse, who gives him the Heimlich maneuver.

As the child of a Hooters waitress and an ex-pro wrestler, Margo Millet's always known she’d have to make it on her own. So she enrolls at her local junior college, even though she can’t imagine how she’ll ever make a living. She’s still figuring things out and never planned to have an affair with her English professor—and while the affair is brief, it isn’t brief enough to keep her from getting pregnant. Despite everyone’s advice, she decides to keep the baby, mostly out of naiveté and a yearning for something bigger.

When Iris decides to move to New York to restart her life, she realizes she underestimated how big the Big Apple really is—all the nostalgic movies set in New York she’d watched with her mom while eating their special secret-recipe gelato didn’t quite do it justice. But Bobby, Iris’s best friend, isn’t about to let her hide away. He drags her to a famous autumn street fair in Little Italy, and as they walk through the food stalls, a little family-run gelateria catches her eye—could it be the same shop that’s in an old photo of her mother’s?

Her name was Henrietta Lacks, but scientists know her as HeLa. She was a poor Southern tobacco farmer who worked the same land as her slave ancestors, yet her cells - taken without her knowledge - became one of the most important tools in medicine: The first “immortal” human cells grown in culture, which are still alive today, though she has been dead for more than 60 years. HeLa cells were vital for developing the polio vaccine; uncovered secrets of cancer, viruses, and the atom bomb’s effects.