Everyone in the small town of Denton is searching for Isabelle Coleman, a missing 17-year-old girl. All they've found so far is her phone and another girl they didn't even know was missing. Mute and completely unresponsive to the world around her, it's clear this mysterious girl has been damaged beyond repair. All Detective Josie Quinn can get from her is a name: Ramona. Currently suspended from the force for misconduct, Josie takes matters into her own hands as the name leads her to evidence linking the two girls.

One question, a split-second decision, and Brian Darby lies dead on the kitchen floor. His wife, state police trooper Tessa Leoni, claims to have shot him in self-defense, and bears the bruises to back up her tale. For veteran detective D. D. Warren it should be an open-and-shut case. But where is their six-year-old daughter?

As a sniper with the elite Massachusetts State Police SWAT Team, Bobby Dodge saved a woman and her young son by shooting her armed husband. But vicious rumors begin to circulate the next morning when Bobby loses his gun and his privileges. It turns out the dead man was the son of a prominent Boston judge and had accused his wife of poisoning their son.

Frankie Elkin is an average middle-aged woman, a recovering alcoholic with more regrets than belongings. But she spends her life doing what no one else will - searching for missing people the world has stopped looking for. When the police have given up, when the public no longer remembers, when the media has never paid attention, Frankie starts looking. A new case brings her to Mattapan, a Boston neighborhood with a rough reputation. She is searching for Angelique Badeau, a Haitian teenager who vanished from her high school months earlier.

When a man is shot in the head, Bree Taggert and her new partner, veteran detective Dana Romano, respond to the call. They break the news to the victim’s ex-wife and learn the estranged couple’s five-year-old daughter was supposed to have been with him. What starts as a murder investigation quickly morphs into a desperate search for a missing child. The case stirs memories of Bree’s own traumatizing childhood. To find the little girl, Bree will have to relive her own terrifying past.