Recently engaged and deeply ensconced in her third year of surgical residency in Chicago, Emily Hartford gets a shock when she is called home to Freeport, Michigan, the small town she fled a decade ago after the death of her mother. Her estranged father, the local medical examiner, has had a massive heart attack. At the hospital, she finds her father in near total denial of the seriousness of his condition. He insists that the best thing Emily can do to help him is to take on the autopsy of a senator's teen daughter whose sudden, unexplained death has just rocked the sleepy town.

When Holly White's fiancé cancels their Christmas Eve wedding with less than two weeks to go, Holly heads home with a broken heart. Lucky for her, home in historic Mistletoe, Maine is magical during Christmastime - exactly what the doctor prescribed. Except her plan to drown her troubles in peppermints and snickerdoodles is upended when local grouch and president of the Mistletoe Historical Society, Margaret Fenwick, is bludgeoned and left in the sleigh display at Reindeer Games, Holly's family tree farm.

July 1989, in a sleepy Michigan town, high school grad Nina Laramie heads out with her friends and is never seen alive again. Months later, her skeleton is found near a remote party spot in the forest. The ME determines Nina has been brutally raped and bludgeoned to death. Fear and anger ripple through this tight-knit community when the case goes cold. Thirty years later, Riley St. James, a Detroit PD assigned to Nina’s case, is determined to get her first big cold case win despite having a similar past to the victim.

Alex Cross is a homicide detective with a Ph.D. in psychology. He works and lives in Southeast D.C. and looks like Muhammad Ali in his prime. He's a tough guy from a tough part of town who wears Harris Tweed jackets and likes to relax by banging out Gershwin tunes on his baby grand piano. But he also has two adorable kids of his own, and they are his own special vulnerabilities.

When a man is shot in the head, Bree Taggert and her new partner, veteran detective Dana Romano, respond to the call. They break the news to the victim’s ex-wife and learn the estranged couple’s five-year-old daughter was supposed to have been with him. What starts as a murder investigation quickly morphs into a desperate search for a missing child. The case stirs memories of Bree’s own traumatizing childhood. To find the little girl, Bree will have to relive her own terrifying past.